A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin (Q41876397)

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scientific article published on 19 February 2008

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English	A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin	scientific article published on 19 February 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin (English)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Saccharomyces cerevisiae

1 reference

based on heuristic

inferred from title

José L. Revuelta

4

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

author name string

Javier Botet

1

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Europe PubMed Central

PMC publication ID

13 October 2017

María Rodríguez-Mateos

2

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Europe PubMed Central

PMC publication ID

13 October 2017

Juan P G Ballesta

3

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Europe PubMed Central

PMC publication ID

13 October 2017

Miguel Remacha

5

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Europe PubMed Central

PMC publication ID

13 October 2017

language of work or name

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publication date

19 February 2008

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Europe PubMed Central

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13 October 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

PMC publication ID

13 October 2017

52

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Europe PubMed Central

PMC publication ID

13 October 2017

5

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

1623-1629

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2346624/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Functional specificity among ribosomal proteins regulates gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346624

5 June 2018

Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2346624

5 June 2018

Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance

1 reference

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5 June 2018

Structure of eEF3 and the mechanism of transfer RNA release from the E-site

1 reference

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Yeast as a tool to uncover the cellular targets of drugs

1 reference

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tRNAGlu wobble uridine methylation by Trm9 identifies Elongator's key role for zymocin-induced cell death in yeast

1 reference

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Yeast as a model for medical and medicinal research

1 reference

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An early step in wobble uridine tRNA modification requires the Elongator complex

1 reference

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Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2

1 reference

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Ribosomal P0 protein domain involved in selectivity of antifungal sordarin derivatives.

1 reference

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Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

1 reference

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Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification.

1 reference

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1 reference

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Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase

1 reference

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Functional profiling of the Saccharomyces cerevisiae genome

1 reference

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Systematic screen for human disease genes in yeast

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Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

1 reference

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KTI11 and KTI13, Saccharomyces cerevisiae genes controlling sensitivity to G1 arrest induced by Kluyveromyces lactis zymocin

1 reference

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Role of the ribosomal stalk components in the resistance of Aspergillus fumigatus to the sordarin antifungals

1 reference

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Species-specific inhibition of fungal protein synthesis by sordarin: identification of a sordarin-specificity region in eukaryotic elongation factor 2.

1 reference

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5 June 2018

Activities of sordarins in experimental models of candidiasis, aspergillosis, and pneumocystosis

1 reference

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5 June 2018

Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution

1 reference

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Gene ontology: tool for the unification of biology

1 reference

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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

1 reference

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Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis

1 reference

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The GTPase center protein L12 is required for correct ribosomal stalk assembly but not for Saccharomyces cerevisiae viability

1 reference

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Sordarins: in vitro activities of new antifungal derivatives against pathogenic yeasts, Pneumocystis carinii, and filamentous fungi

1 reference

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Translation elongation factor 2 is part of the target for a new family of antifungals

1 reference

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Ribosomal P-protein stalk function is targeted by sordarin antifungals.

1 reference

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Identification of elongation factor 2 as the essential protein targeted by sordarins in Candida albicans

1 reference

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Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts

1 reference

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Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition

1 reference

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Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene.

1 reference

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The DuplicatedSaccharomyces cerevisiaeGeneSSM1Encodes a Eucaryotic Homolog of the Eubacterial and Archaebacterial L1 Ribosomal Proteins

1 reference

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Ribosomal Acidic Phosphoproteins P1 and P2 Are Not Required for Cell Viability but Regulate the Pattern of Protein Expression in Saccharomyces cerevisiae

1 reference

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ADP-ribosylation of elongation factor 2 by diphtheria toxin. Isolation and properties of the novel ribosyl-amino acid and its hydrolysis products

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DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae

1 reference

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1 reference

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Crystal structure of ADP-ribosylated ribosomal translocase from Saccharomyces cerevisiae

1 reference

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Mutations in ribosomal protein L10e confer resistance to the fungal-specific eukaryotic elongation factor 2 inhibitor sordarin.

1 reference

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https://pubmed.ncbi.nlm.nih.gov/18285480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elongation factor 2 as a novel target for selective inhibition of fungal protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18285480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of ribosomal protein P0 is not essential for ribosome function but can affect translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18285480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and Characterisation of an Antifungal Antibiotic (GR135402) with Protein Synthesis Inhibition.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.51.41

Identifiers

10.1128/AAC.01603-07

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

ResearchGate publication ID

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