Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation (Q41896006)

13 October 2017

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation (English)

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13 October 2017

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Yoshihiko Ichikawa

1

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13 October 2017

Mohsen Ghanefar

2

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13 October 2017

Marina Bayeva

3

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13 October 2017

Rongxue Wu

4

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13 October 2017

Arineh Khechaduri

5

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13 October 2017

Sathyamangla V Naga Prasad

6

1 reference

13 October 2017

R Kannan Mutharasan

7

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13 October 2017

Tejaswitha Jairaj Naik

8

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13 October 2017

Hossein Ardehali

9

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13 October 2017

language of work or name

English

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publication date

2 January 2014

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Journal of Clinical Investigation

13 October 2017

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13 October 2017

124

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13 October 2017

2

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13 October 2017

617-630

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describes a project that uses

13 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3904631/fullTextXML

inferred from PubMed Central ID database lookup

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Iron chelators with topoisomerase-inhibitory activity and their anticancer applications

5 June 2018

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Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export

5 June 2018

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5 June 2018

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Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial

5 June 2018

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Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the children's oncology group

5 June 2018

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Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron

5 June 2018

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Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo.

5 June 2018

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Iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking.

5 June 2018

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Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?

5 June 2018

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Assessment of chelatable mitochondrial iron by using mitochondrion-selective fluorescent iron indicators with different iron-binding affinities

5 June 2018

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Anthracycline cardiotoxicity

5 June 2018

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Adriamycin-induced oxidative mitochondrial cardiotoxicity

5 June 2018

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Targeting of the mitochondrial membrane proteins to the cell surface for functional studies

5 June 2018

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Molecular pharmacology of the interaction of anthracyclines with iron

5 June 2018

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Transcriptional regulation of myotube fate specification and intrafusal muscle fiber morphogenesis

5 June 2018

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The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: expert panel review.

5 June 2018

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Anthracyclines: selected new developments

5 June 2018

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Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor

5 June 2018

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The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.

5 June 2018

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The role of iron in doxorubicin-induced cardiomyopathy.

5 June 2018

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Chelation therapy in cardiovascular disease: ethylenediaminetetraacetic acid, deferoxamine, and dexrazoxane

5 June 2018

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Pathogenesis and prevention of doxorubicin cardiomyopathy

5 June 2018

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Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer.

5 June 2018

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Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes

5 June 2018

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Comparison of the protective effects of desferrioxamine and ICRF-187 against doxorubicin-induced toxicity in spontaneously hypertensive rats

5 June 2018

1 reference

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Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles

5 June 2018

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Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity

5 June 2018

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Doxorubicin-induced cardiac dysfunction is attenuated by ciclosporin treatment in mice through improvements in mitochondrial bioenergetics

5 June 2018

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Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways

18 August 2018

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Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy

18 August 2018

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The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin

18 August 2018

1 reference

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Dexrazoxane (ICRF-187) Protects Cardiac Myocytes Against Doxorubicin by Preventing Damage to Mitochondria

18 August 2018

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Doxorubicin-derived metabolites induce release of cytochrome C and inhibition of respiration on cardiac isolated mitochondria.

18 August 2018

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Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin

18 August 2018

1 reference

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Anthracyclines induce accumulation of iron in ferritin in myocardial and neoplastic cells: inhibition of the ferritin iron mobilization pathway

18 August 2018

1 reference

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Doxorubicin irreversibly inactivates iron regulatory proteins 1 and 2 in cardiomyocytes: evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904631

Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin's disease

18 August 2018

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12 December 2020

Potentiation of Doxorubicin cardiotoxicity by iron loading in a rodent model

1 reference

12 December 2020

Synthesis and solution properties of deferoxamine amides

1 reference

12 December 2020

Unexpected anthracycline-mediated alterations in iron-regulatory protein-RNA-binding activity: the iron and copper complexes of anthracyclines decrease RNA-binding activity

1 reference

12 December 2020

Mitochondrial iron not bound in heme and iron-sulfur centers. Estimation, compartmentation and redox state

1 reference

12 December 2020

Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex

1 reference

12 December 2020

Examination of the potential long-lasting protective effect of ICRF-187 against anthracycline-induced chronic cardiomyopathy

1 reference

12 December 2020

Anthracycline toxicity is potentiated by iron and inhibited by deferoxamine: studies in rat heart cells in culture

1 reference

12 December 2020

Subcellular distribution of desferrioxamine and hydroxypyridin-4-one chelators in K562 cells affects chelation of intracellular iron pools

1 reference

12 December 2020

Chelation and mobilization of cellular iron by different classes of chelators

1 reference

12 December 2020

Catalytic inhibitors of DNA topoisomerase II

1 reference

12 December 2020

Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI72931

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

24382354

1 reference