NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression (Q41917631)

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4 January 2020

title

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression (English)

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4 January 2020

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1

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author name string

J Harder

2

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4 January 2020

M Weichenthal

3

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4 January 2020

M Schwab

4

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4 January 2020

E Schäffeler

5

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M Schlee

6

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K R Herrlinger

7

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A Stallmach

8

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F Noack

9

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P Fritz

10

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J M Schröder

11

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C L Bevins

12

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K Fellermann

13

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E F Stange

14

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language of work or name

English

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publication date

1 November 2004

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4 January 2020

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4 January 2020

volume

53

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4 January 2020

issue

11

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4 January 2020

page(s)

1658-1664

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Crohn's disease and the NOD2 gene: a role for paneth cells

4 January 2020

cites work

1 reference

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Crohn's disease: a defensin deficiency syndrome?

5 June 2018

1 reference

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Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon

5 June 2018

1 reference

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CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

5 June 2018

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Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

5 June 2018

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Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expression

5 June 2018

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Innate immunity and colonic inflammation: enhanced expression of epithelial alpha-defensins

5 June 2018

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The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease

5 June 2018

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The bacterial flora in inflammatory bowel disease: current insights in pathogenesis and the influence of antibiotics and probiotics

5 June 2018

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Familial expression of anti-Saccharomyces cerevisiae Mannan antibodies in Crohn's disease and ulcerative colitis: a GISC study

5 June 2018

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Defensins -- innate immunity at the epithelial frontier

5 June 2018

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

5 June 2018

1 reference

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

5 June 2018

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Epithelial antimicrobial peptides: innate local host response elements

5 June 2018

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Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes

5 June 2018

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Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease

5 June 2018

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Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

5 June 2018

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Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays

5 June 2018

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Identification of a novel bacterial sequence associated with Crohn's disease

5 June 2018

1 reference

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Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense

5 June 2018

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T cell specificity and cross reactivity towards enterobacteria, bacteroides, bifidobacterium, and antigens from resident intestinal flora in humans

5 June 2018

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Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice

5 June 2018

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Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils

5 June 2018

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Changes in the Paneth cell population of human small intestine assessed by image analysis of the secretory granule area

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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18 August 2018

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18 August 2018

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18 August 2018

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18 August 2018

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18 August 2018

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12 December 2020

Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease

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12 December 2020

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

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12 December 2020

Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease

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12 December 2020

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12 December 2020

The genetics of inflammatory bowel disease

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12 December 2020

Crohn's disease: transmission electron microscopic studies. I. Barrier function. Possible changes related to alterations of cell coat, mucous coat, epithelial cells, and Paneth cells

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12 December 2020

Mycobacterium paratuberculosis in intestinal tissue from patients with Crohn's disease demonstrated by a nested primer polymerase chain reaction

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12 December 2020

Identifiers

DOI

10.1136/GUT.2003.032805

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15479689%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15479689%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

15479689

1 reference