Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells. (Q42128057)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20483725%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells (English)

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2 February 2020

3

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2 February 2020

author name string

Diana M Mitchell

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20483725%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Eugene V Ravkov

series ordinal

2

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2 February 2020

language of work or name

English

0 references

publication date

14 May 2010

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2 February 2020

published in

Journal of Immunology

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2 February 2020

volume

184

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2 February 2020

issue

12

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2 February 2020

page(s)

6719-6730

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Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells

2 February 2020

cites work

1 reference

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CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses

29 May 2018

1 reference

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A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

29 May 2018

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Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses

29 May 2018

1 reference

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Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties

29 May 2018

1 reference

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Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory

29 May 2018

1 reference

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A vital role for interleukin-21 in the control of a chronic viral infection

29 May 2018

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IL-21 is required to control chronic viral infection

29 May 2018

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IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment

29 May 2018

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Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

29 May 2018

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Homeostasis of naive and memory T cells

29 May 2018

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Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation

29 May 2018

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IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response

29 May 2018

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Regulation and functions of Blimp-1 in T and B lymphocytes

29 May 2018

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Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory

29 May 2018

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A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions

29 May 2018

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Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation

29 May 2018

1 reference

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Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

29 May 2018

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Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection

29 May 2018

1 reference

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Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor

29 May 2018

1 reference

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Development of smallpox vaccine candidates with integrated interleukin-15 that demonstrate superior immunogenicity, efficacy, and safety in mice

29 May 2018

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Common gamma chain cytokines: dissidence in the details

29 May 2018

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Effector and memory CTL differentiation

29 May 2018

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The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

29 May 2018

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Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program

29 May 2018

1 reference

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Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

29 May 2018

1 reference

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Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype.

29 May 2018

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Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

29 May 2018

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

29 May 2018

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Initial T cell frequency dictates memory CD8+ T cell lineage commitment

29 May 2018

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Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

29 May 2018

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Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

29 May 2018

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Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6

29 May 2018

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Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis

29 May 2018

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Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance

29 May 2018

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Tolerance, not immunity, crucially depends on IL-2.

29 May 2018

1 reference

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Helping the CD8(+) T-cell response

29 May 2018

1 reference

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IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

29 May 2018

1 reference

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Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

29 May 2018

1 reference

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Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

29 May 2018

1 reference

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Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity

29 May 2018

1 reference

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CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

29 May 2018

1 reference

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Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

29 May 2018

1 reference

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Migratory properties of naive, effector, and memory CD8(+) T cells

29 May 2018

1 reference

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Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

29 May 2018

1 reference

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Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

29 May 2018

1 reference

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High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993

29 May 2018

1 reference

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Phenotypic analysis of antigen-specific T lymphocytes

29 May 2018

1 reference

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Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes

29 May 2018

1 reference

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Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity

29 May 2018

1 reference

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Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus

29 May 2018

1 reference

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Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

29 May 2018

1 reference

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IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

17 August 2018

1 reference

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Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA + IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques

17 August 2018

1 reference

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Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

17 August 2018

1 reference

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Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.

17 August 2018

1 reference

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Shortening the infectious period does not alter expansion of CD8 T cells but diminishes their capacity to differentiate into memory cells

17 August 2018

1 reference

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Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

Overexpression of interleukin-15 in vivo enhances antitumor activity against MHC class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2950111

Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression

17 August 2018

1 reference

12 December 2020

Cytokine therapy in cancer

1 reference

12 December 2020

Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors

1 reference

12 December 2020

Dynamic programming of CD8+ T lymphocyte responses

1 reference

12 December 2020

Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2

1 reference

12 December 2020

Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0904089

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20483725%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20483725%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

20483725

1 reference