Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation (Q42149962)

17 October 2017

Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation (English)

1 reference

17 October 2017

Naniye Cetinbas

1

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17 October 2017

Helen Huang-Hobbs

2

1 reference

17 October 2017

Cristina Tognon

3

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17 October 2017

Gabriel Leprivier

4

1 reference

17 October 2017

Jianghong An

5

1 reference

17 October 2017

Steven McKinney

6

1 reference

17 October 2017

Mary Bowden

7

1 reference

17 October 2017

Connie Chow

8

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17 October 2017

Martin Gleave

9

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17 October 2017

Lawrence P McIntosh

10

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17 October 2017

Poul H Sorensen

11

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17 October 2017

language of work or name

English

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publication date

24 June 2013

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Journal of Biological Chemistry

17 October 2017

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17 October 2017

288

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17 October 2017

39

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17 October 2017

27940-27950

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describes a project that uses

17 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3784708/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis

29 May 2018

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Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.

29 May 2018

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Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function.

29 May 2018

1 reference

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Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence

29 May 2018

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29 May 2018

The many faces of SAM

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ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages

29 May 2018

1 reference

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ETV6: a versatile player in leukemogenesis.

29 May 2018

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29 May 2018

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Derepression by depolymerization; structural insights into the regulation of Yan by Mae.

29 May 2018

1 reference

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Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor

29 May 2018

1 reference

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Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma

29 May 2018

1 reference

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Native interface of the SAM domain polymer of TEL.

29 May 2018

1 reference

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ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation

29 May 2018

1 reference

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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

29 May 2018

1 reference

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The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

29 May 2018

1 reference

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Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).

29 May 2018

1 reference

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Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25).

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

The TEL gene products: nuclear phosphoproteins with DNA binding properties

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

SAM as a protein interaction domain involved in developmental regulation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteins

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

The novel activation of ABL by fusion to an ets-related gene, TEL.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

The SAM domain of polyhomeotic, RAE28, and scm mediates specific interactions through conserved residues.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784708

ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23798677

12 December 2020

inferred from PubMed ID database lookup

Mammary-type secretory carcinoma of the skin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23798677

12 December 2020

inferred from PubMed ID database lookup

Chronic eosinophilic leukaemia with ETV6-NTRK3 fusion transcript in an elderly patient affected with pancreatic carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23798677

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M113.475301

1 reference

17 October 2017

1 reference

17 October 2017

PubMed publication ID

23798677

1 reference