Phorbol esters enhance 1α,25-dihydroxyvitamin D3-regulated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells (Q42267612)

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scientific article published on 28 March 2012

Language	Label	Description	Also known as
English	Phorbol esters enhance 1α,25-dihydroxyvitamin D3-regulated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells	scientific article published on 28 March 2012

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

Phorbol esters enhance 1α,25-dihydroxyvitamin D3-regulated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells (English)

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

phosphorylation

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Yan Jiang

1

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

James C Fleet

2

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

publication date

28 March 2012

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

Molecular and Cellular Endocrinology

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

361

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

1-2

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

31-39

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

Effect of phorbol 12-myristate 13-acetate activated signaling pathways on 1α, 25 dihydroxyvitamin D3 regulated human 25-hydroxyvitamin D3 24-hydroxylase gene expression in differentiated Caco-2 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

A role for the phosphatidylinositol 3-kinase--protein kinase C zeta--Sp1 pathway in the 1,25-dihydroxyvitamin D3 induction of the 25-hydroxyvitamin D3 24-hydroxylase gene in human kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

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Effects of vitamin d and calcium on proliferation and differentiation in normal colon mucosa: a randomized clinical trial

1 reference

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26 October 2017

Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

The effect of differentiation on 1,25 dihydroxyvitamin D-mediated gene expression in the enterocyte-like cell line, Caco-2

1 reference

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Mitogen activated protein kinases (MAPKs) as regulators of spermatogenesis and spermatozoa functions

1 reference

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Sp3-mediated VEGF regulation is dependent on phosphorylation by extra-cellular signals regulated kinases (Erk).

1 reference

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26 October 2017

Phorbol 12-myristate 13-acetate (PMA)-induced migration of glioblastoma cells is mediated via p38MAPK/Hsp27 pathway

1 reference

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A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model

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26 October 2017

Characterizing early events associated with the activation of target genes by 1,25-dihydroxyvitamin D3 in mouse kidney and intestine in vivo

1 reference

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26 October 2017

p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1

1 reference

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26 October 2017

Nucleo-cytoplasmic cycling of the vitamin D receptor in the enterocyte-like cell line, Caco-2.

1 reference

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26 October 2017

Role of p38 in stress activation of Sp1.

1 reference

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26 October 2017

The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells

1 reference

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26 October 2017

Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex

1 reference

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26 October 2017

Molecular action of 1,25-dihydroxyvitamin D3 and phorbol ester on the activation of the rat cytochrome P450C24 (CYP24) promoter: role of MAP kinase activities and identification of an important transcription factor binding site

1 reference

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26 October 2017

Gene regulation by Sp1 and Sp3.

1 reference

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26 October 2017

Complexity of translationally controlled transcription factor Sp3 isoform expression.

1 reference

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26 October 2017

Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha

1 reference

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26 October 2017

ConSite: web-based prediction of regulatory elements using cross-species comparison

1 reference

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26 October 2017

Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42/44MAPK and transcription factor Sp3.

1 reference

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26 October 2017

TRANSFAC: transcriptional regulation, from patterns to profiles

1 reference

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26 October 2017

Vitamin D-inducible calcium transport and gene expression in three Caco-2 cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Pharmacological inhibitors of MAPK pathways.

1 reference

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26 October 2017

Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Increased vitamin D receptor level enhances 1,25-dihydroxyvitamin D3-mediated gene expression and calcium transport in Caco-2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Differential responsiveness of intestinal epithelial cells to 1,25-dihydroxyvitamin D3--role of protein kinase C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Nuclear receptors modulate the interaction of Sp1 and GC-rich DNA via ternary complex formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Liarozole acts synergistically with 1alpha,25-dihydroxyvitamin D3 to inhibit growth of DU 145 human prostate cancer cells by blocking 24-hydroxylase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

COUP-TF upregulates NGFI-A gene expression through an Sp1 binding site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Transcriptional synergism between vitamin D-responsive elements in the rat 25-hydroxyvitamin D3 24-hydroxylase (CYP24) promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Phorbol ester markedly increases the sensitivity of intestinal epithelial cells to 1,25-dihydroxyvitamin D3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

1,25-Dihydroxyvitamin D3 translocates protein kinase C beta to nucleus and enhances plasma membrane association of protein kinase C alpha in renal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Protein kinase C is involved in 24-hydroxylase gene expression induced by 1,25(OH)2D3 in rat intestinal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Transcriptional synergism between the vitamin D3 receptor and other nonreceptor transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Cloning of the human 1α,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

An analysis of intestinal calcium transport across the rat intestine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Mithramycin blocks protein binding and function of the SV40 early promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Synergistic action of the glucocorticoid receptor with transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Target Detection Assay (TDA): a versatile procedure to determine DNA binding sites as demonstrated on SP1 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Developmental expression of Sp1 in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

26 October 2017

Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

29 May 2018

Calcitonin stimulates expression of the rat 25-hydroxyvitamin D3-24-hydroxylase (CYP24) promoter in HEK-293 cells expressing calcitonin receptor: identification of signaling pathways

1 reference

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29 May 2018

A Crucial Role for the Vitamin D Receptor in Experimental Inflammatory Bowel Diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

29 May 2018

Specific 1,25(OH)2D3-mediated regulation of transcellular calcium transport in Caco-2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

29 May 2018

Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals.

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

29 May 2018

https://pubmed.ncbi.nlm.nih.gov/22871965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progesterone regulates transcription of the p21(WAF1) cyclin- dependent kinase inhibitor gene through Sp1 and CBP/p300.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

29 May 2018

Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

29 May 2018

1,25-dihydroxyvitamin D3 transcriptionally represses p45Skp2 expression via the Sp1 sites in human prostate cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

17 August 2018

Effect of cellular environment on the selective activation of the vitamin D receptor by 1alpha,25-dihydroxyvitamin D3 and its analog 1alpha-fluoro-16-ene-20-epi-23-ene-26,27-bishomo-25-hydroxyvitamin D3 (Ro-26-9228).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

17 August 2018

PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

17 August 2018

Integration of hormone signaling in the regulation of human 25(OH)D3 24-hydroxylase transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

17 August 2018

Calcium transporter 1 and epithelial calcium channel messenger ribonucleic acid are differentially regulated by 1,25 dihydroxyvitamin D3 in the intestine and kidney of mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

17 August 2018

Differentiation state-selective roles of p38 isoforms in human intestinal epithelial cell anoikis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414851

17 August 2018

Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D

1 reference

https://pubmed.ncbi.nlm.nih.gov/22871965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22871965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of Sp transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22871965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A

1 reference

https://pubmed.ncbi.nlm.nih.gov/22871965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Many transcription factors interact synergistically with steroid receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22871965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 1,25-dihydroxyvitamin D3 and phorbol ester on 25-hydroxyvitamin D3 24-hydroxylase cytochrome P450 messenger ribonucleic acid levels in primary cultures of rat renal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22871965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of distal upstream sequence in vitamin D-induced expression of human CYP24 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22871965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.MCE.2012.03.008

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release_syaxegvauvfotfstdguxpij4ze

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https://api.fatcat.wiki/v0/release/syaxegvauvfotfstdguxpij4ze

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https://api.fatcat.wiki/v0/release/syaxegvauvfotfstdguxpij4ze

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