Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. (Q42282551)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20881279%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma (English)

1 reference

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14 February 2020

0 references

15

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14 February 2020

author name string

Silvia Buonamici

1

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14 February 2020

Juliet Williams

2

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14 February 2020

Michael Morrissey

3

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14 February 2020

Anlai Wang

4

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14 February 2020

Ribo Guo

5

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14 February 2020

Anthony Vattay

6

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14 February 2020

Kathy Hsiao

7

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14 February 2020

Jing Yuan

8

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14 February 2020

John Green

9

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14 February 2020

Beatriz Ospina

10

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14 February 2020

Qunyan Yu

11

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Lance Ostrom

12

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14 February 2020

Paul Fordjour

13

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14 February 2020

Dustin L Anderson

14

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14 February 2020

Joseph F Kelleher

16

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14 February 2020

Stefan Peukert

17

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14 February 2020

Shifeng Pan

18

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14 February 2020

Xu Wu

19

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14 February 2020

Sauveur-Michel Maira

20

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14 February 2020

Carlos García-Echeverría

21

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14 February 2020

Kimberly J Briggs

22

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14 February 2020

D Neil Watkins

23

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14 February 2020

Yung-mae Yao

24

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Christoph Lengauer

25

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14 February 2020

Markus Warmuth

26

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14 February 2020

William R Sellers

27

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14 February 2020

Marion Dorsch

28

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language of work or name

English

0 references

publication date

1 September 2010

1 reference

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Science Translational Medicine

14 February 2020

published in

1 reference

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14 February 2020

volume

2

1 reference

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14 February 2020

issue

51

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14 February 2020

page(s)

51ra70

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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

14 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422576

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422576

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

26 October 2017

1 reference

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Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy

26 October 2017

1 reference

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Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422576

Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice

26 October 2017

1 reference

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Hedgehog: functions and mechanisms

26 October 2017

1 reference

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PTEN-deficient cancers depend on PIK3CB.

26 October 2017

1 reference

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A paracrine requirement for hedgehog signalling in cancer

26 October 2017

1 reference

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

26 October 2017

1 reference

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Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma

26 October 2017

1 reference

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Acquired resistance to tyrosine kinase inhibitors during cancer therapy

26 October 2017

1 reference

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Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422576

Pathway mapping tools for analysis of high content data

26 October 2017

1 reference

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Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

26 October 2017

1 reference

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GLI transcription factors: mediators of oncogenic Hedgehog signalling

26 October 2017

1 reference

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Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice

26 October 2017

1 reference

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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

26 October 2017

1 reference

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Hedgehog signalling in cancer

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422576

More powerful procedures for multiple significance testing

26 October 2017

1 reference

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1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

26 October 2017

1 reference

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Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

17 August 2018

1 reference

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Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422576

Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors.

17 August 2018

1 reference

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Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422576

10.1126/SCITRANSLMED.3001599

17 August 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20881279%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20881279%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

PubMed publication ID

20881279

1 reference