Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates (Q42497379)

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English	Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 November 2017

Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

author name string

Kerr KM

1

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Europe PubMed Central

PubMed publication ID

1 November 2017

Sauna ZE

2

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1 November 2017

Ambudkar SV

3

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Europe PubMed Central

PubMed publication ID

1 November 2017

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publication date

19 December 2000

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1 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

1 November 2017

276

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Europe PubMed Central

PubMed publication ID

1 November 2017

12

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Europe PubMed Central

PubMed publication ID

1 November 2017

8657-8664

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

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Genetic analysis of the multidrug transporter

1 reference

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Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

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P-glycoprotein and multidrug resistance

1 reference

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Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system

1 reference

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Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

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Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells

1 reference

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Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

1 reference

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21 January 2018

ATPase activity of Chinese hamster P-glycoprotein

1 reference

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21 January 2018

Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein

1 reference

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The effects of lipids and detergents on ATPase-active P-glycoprotein

1 reference

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The P-glycoprotein multidrug transporter: interactions with membrane lipids, and their modulation of activity

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The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter

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Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains

1 reference

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P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

1 reference

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Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

1 reference

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21 January 2018

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites

1 reference

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21 January 2018

The catalytic cycle of P-glycoprotein

1 reference

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Baculovirus-mediated expression of human multidrug resistance cDNA in insect cells and functional analysis of recombinant P-glycoprotein

1 reference

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Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

1 reference

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Purification and reconstitution of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010044200

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Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010044200

21 January 2018

Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010044200

21 January 2018

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010044200

21 January 2018

Effects of cardiovascular drugs on ATPase activity of P-glycoprotein in plasma membranes and in purified reconstituted form

1 reference

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21 January 2018

Competitive and non-competitive inhibition of the multidrug-resistance-associated P-glycoprotein ATPase--further experimental evidence for a multisite model

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HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

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Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

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A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol.

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21 January 2018

Identification of the cyclosporin-binding site in P-glycoprotein

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Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

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Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein

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ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

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21 January 2018

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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21 January 2018

P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity

1 reference

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Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

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Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease

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Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M010044200

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

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