The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. (Q42523817)

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English	The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury.	scientific article

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11 November 2019

The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury (English)

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11 November 2019

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Steven T. DeKosky

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11 November 2019

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Anirban Basu

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11 November 2019

J Kyle Krady

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11 November 2019

Mark O'Malley

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11 November 2019

Scott D Styren

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11 November 2019

Steven W Levison

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11 November 2019

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1 July 2002

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11 November 2019

Journal of Neuroscience

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11 November 2019

22

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11 November 2019

14

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11 November 2019

6071-6082

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11 November 2019

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6757935/fullTextXML

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Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice

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Leptin actions on food intake and body temperature are mediated by IL-1

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Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2

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Quantitative changes in interleukin proteins following focal stroke in the rat

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Inflammation and Alzheimer's disease

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Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration

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The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk

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Interleukin-1 receptor type I gene-deficient mice are less susceptible to Staphylococcus epidermidis biomaterial-associated infection than are wild-type mice.

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Interleukin 1 in the brain: biology, pathology and therapeutic target

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Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival

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Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha

1 reference

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Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

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12 December 2020

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Evaluation of IL-2, sIL2R, IL-6, TNF-alpha, and IL-1 beta levels in serum and CSF of patients with optic neuritis

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Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-κ B-like nuclear protein

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Induction of interleukin-1 beta mRNA in rat brain after transient forebrain ischemia

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Transforming growth factor-beta 1 (TGF-β1) expression and regulation in rat cortical astrocytes

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Mechanism of nerve growth factor mRNA regulation by interleukin-1 and basic fibroblast growth factor in primary cultures of rat astrocytes

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Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes

1 reference

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https://pubmed.ncbi.nlm.nih.gov/12122068

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Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

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Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

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https://pubmed.ncbi.nlm.nih.gov/12122068

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Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution.

1 reference

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Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha

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https://pubmed.ncbi.nlm.nih.gov/12122068

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Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6

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Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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inferred from PubMed ID database lookup

Regulation of nerve growth factor mRNA by interleukin-1 in rat hippocampal astrocytes is mediated by NFkappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired neuroglial activation in interleukin-6 deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12122068

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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1 reference

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1 reference

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based on heuristic

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Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice

1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

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1 reference

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inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-14-06071.2002

1 reference

Europe PubMed Central

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11 November 2019

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Europe PubMed Central

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11 November 2019

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12122068%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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