Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity (Q42703006)

5 November 2017

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity (English)

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5 November 2017

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O Osborn

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Manuel Sanchez-Alavez

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M Sanchez-Alavez

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Tamas Bartfai

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T Bartfai

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5 November 2017

S E Brownell

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5 November 2017

D Salomon

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5 November 2017

H Gram

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23 August 2008

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141-148

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describes a project that uses

5 November 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3063393/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia

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Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage

27 May 2018

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New agents in development for the management of obesity

27 May 2018

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27 May 2018

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Altered proinsulin conversion in rat pancreatic islets exposed long-term to various glucose concentrations or interleukin-1beta

27 May 2018

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27 May 2018

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Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression

27 May 2018

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IL-1 resets glucose homeostasis at central levels

27 May 2018

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Endocrine and signalling role of adipose tissue: new perspectives on fat.

27 May 2018

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Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute [...]

27 May 2018

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Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance

27 May 2018

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Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide.

27 May 2018

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Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

27 May 2018

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Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention

27 May 2018

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Inflammation-sensitive plasma proteins are associated with future weight gain

27 May 2018

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Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

27 May 2018

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A rational approach to pathogenesis and treatment of type 2 diabetes mellitus, insulin resistance, inflammation, and atherosclerosis

27 May 2018

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The balance between IL-1 and IL-1Ra in disease

27 May 2018

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Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings

27 May 2018

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Proinflammation: a common denominator or initiator of different pathophysiological disease processes.

27 May 2018

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Proinflammatory cytokines in heart disease

27 May 2018

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Measurement of insulin resistance in vivo

27 May 2018

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IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation.

27 May 2018

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C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?

27 May 2018

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How to measure insulin sensitivity

27 May 2018

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The interleukin-1 system: receptors, ligands, and ICE in the brain and their involvement in the fever response

27 May 2018

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Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases

27 May 2018

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Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid

27 May 2018

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Hyperresponsive febrile reactions to interleukin (IL) 1alpha and IL-1beta, and altered brain cytokine mRNA and serum cytokine levels, in IL-1beta-deficient mice

27 May 2018

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The role of interleukin-1 in the pathogenesis of IDDM.

27 May 2018

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Biologic basis for interleukin-1 in disease

27 May 2018

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Cytokines in neuronal cell types

27 May 2018

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Positional cloning of the mouse obese gene and its human homologue

27 May 2018

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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus

27 May 2018

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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

27 May 2018

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

27 May 2018

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Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

27 May 2018

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Neuroendocrine and metabolic responses induced by interleukin-1.

27 May 2018

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Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus

27 May 2018

1 reference

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Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist

27 May 2018

1 reference

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An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1?

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063393

The Glycosylation of Hemoglobin: Relevance to Diabetes Mellitus

27 May 2018

1 reference

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Neuroendocrine, sympathetic and metabolic responses induced by interleukin-1.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063393

Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents.

27 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063393

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective po

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063393

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063393

Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063393

IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063393

Contribution to glucose tolerance of insulin-independent vs. insulin-dependent mechanisms in mice

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063393

Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response

16 August 2018

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12 December 2020

Protection from experimental autoimmune diabetes in the non-obese diabetic mouse with soluble interleukin-1 receptor

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12 December 2020

The metabolic effects of interleukin 1 beta on human bone marrow adipocytes

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12 December 2020

Soluble murine IL-1 receptor type I induces release of constitutive IL-1 alpha

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12 December 2020

Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice

1 reference

12 December 2020

Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice

1 reference

12 December 2020

Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes

1 reference

12 December 2020

Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy

1 reference

12 December 2020

The relation of body fat mass and distribution to markers of chronic inflammation

1 reference

12 December 2020

IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin?

1 reference

12 December 2020

Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production

1 reference

12 December 2020

Is type 2 diabetes a chronic inflammatory/autoimmune disease?

1 reference

12 December 2020

Adipose tissue is a major source of interleukin-1 receptor antagonist: upregulation in obesity and inflammation

1 reference

12 December 2020

Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans

1 reference

12 December 2020

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity

1 reference

12 December 2020

Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats

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12 December 2020

10.1016/J.CYTO.2008.07.004

Identifiers

DOI

1 reference

5 November 2017

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5 November 2017

PubMed publication ID

18723371

1 reference