Factors affecting the in vivo lactone stability and systemic clearance of the lipophilic camptothecin analogue AR-67. (Q43080807)

13 November 2017

title

Factors affecting the in vivo lactone stability and systemic clearance of the lipophilic camptothecin analogue AR-67. (English)

1 reference

13 November 2017

Eyob D Adane

1

1 reference

13 November 2017

Zhiwei Liu

2

1 reference

13 November 2017

Tian-Xiang Xiang

3

1 reference

13 November 2017

Bradley D Anderson

4

1 reference

13 November 2017

Markos Leggas

5

1 reference

13 November 2017

language of work or name

1 reference

29 April 2010

1 reference

13 November 2017

published in

Pharmaceutical Research

1 reference

13 November 2017

volume

27

1 reference

13 November 2017

issue

7

1 reference

13 November 2017

page(s)

1416-1425

1 reference

In vitro transport of gimatecan (7-t-butoxyiminomethylcamptothecin) by breast cancer resistance protein, P-glycoprotein, and multidrug resistance protein 2.

13 November 2017

cites work

1 reference

12 December 2020

Pharmacokinetics of reversible metabolic systems

1 reference

12 December 2020

Mean residence times and distribution volumes for drugs undergoing linear reversible metabolism and tissue distribution and linear or nonlinear elimination from the central compartments

1 reference

12 December 2020

Differential interactions of camptothecin lactone and carboxylate forms with human blood components

1 reference

12 December 2020

Potent topoisomerase I inhibition by novel silatecans eliminates glioma proliferation in vitro and in vivo

1 reference

12 December 2020

Phase I clinical and pharmacological studies of 20-(S)-camptothecin and 20-(S)-9-nitrocamptothecin as anticancer agents

1 reference

12 December 2020

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers

1 reference

12 December 2020

Plasma camptothecin (NSC-100880) levels during a 5-day course of treatment: relation to dose and toxicity.

1 reference

12 December 2020

Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

1 reference

12 December 2020

Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells

1 reference

12 December 2020

Urinary and biliary disposition of the lactone and carboxylate forms of 20(S)-camptothecin in rats.

1 reference

12 December 2020

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

1 reference

12 December 2020

A phase I study of 7-t-butyldimethylsilyl-10-hydroxycamptothecin in adult patients with refractory or metastatic solid malignancies

1 reference

12 December 2020

Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems

1 reference

12 December 2020

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

1 reference

12 December 2020

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

1 reference

12 December 2020

Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.

1 reference

12 December 2020

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

1 reference

12 December 2020

A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues

1 reference

12 December 2020

Plasma pharmacokinetics of lactone and carboxylate forms of 20(S)-camptothecin in anesthetized rats

1 reference

12 December 2020

Validation of an HPLC method for analysis of DB-67 and its water soluble prodrug in mouse plasma

1 reference

12 December 2020

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

1 reference

12 December 2020

Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors

1 reference

12 December 2020

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin

1 reference

12 December 2020

The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog.

1 reference

12 December 2020

Modulation of P-glycoprotein Transport Activity in the Mouse Blood-Brain Barrier by Rifampin

1 reference

12 December 2020

Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism

1 reference

12 December 2020

The novel silatecan 7-tert-butyldimethylsilyl-10-hydroxycamptothecin displays high lipophilicity, improved human blood stability, and potent anticancer activity

1 reference

12 December 2020

The determination of essential clearance, volume, and residence time parameters of recirculating metabolic systems: the reversible metabolism of methylprednisolone and methylprednisone in rabbits

1 reference

12 December 2020

Kinetics of the in vivo interconversion of the carboxylate and lactone forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients

1 reference

12 December 2020

A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients

1 reference

12 December 2020

Pharmacokinetics of camptothecins administered orally

1 reference

12 December 2020

Preferential binding of the carboxylate form of camptothecin by human serum albumin

1 reference

12 December 2020

10.1007/S11095-010-0137-3

Identifiers

DOI

1 reference

13 November 2017

1 reference