Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates. (Q43151994)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18313382%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18313382%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1

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3 January 2020

Robert T Sauer

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18313382%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

author name string

Tania A Baker

series ordinal

2

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3 January 2020

publication date

1 February 2008

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18313382%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18313382%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

volume

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18313382%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

issue

4

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3 January 2020

page(s)

441-450

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18313382%20AND%20SRC:MED&resulttype=core&format=json

Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease

3 January 2020

cites work

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Altered specificity of a AAA+ protease.

25 May 2018

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Mechanism of DNA translocation in a replicative hexameric helicase

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25 May 2018

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AAA+ proteins: have engine, will work

25 May 2018

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Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

25 May 2018

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Protein unfolding in the cell

25 May 2018

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25 May 2018

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SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags

25 May 2018

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Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates

25 May 2018

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Structure of a Delivery Protein for an AAA+ Protease in Complex with a Peptide Degradation Tag

25 May 2018

1 reference

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Crystal Structure of ClpX Molecular Chaperone from Helicobacter pylori

25 May 2018

1 reference

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Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine

25 May 2018

1 reference

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Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP

25 May 2018

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Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU

25 May 2018

1 reference

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Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

Mutational studies on HslU and its docking mode with HslV

25 May 2018

1 reference

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Crystal and solution structures of an HslUV protease-chaperone complex

25 May 2018

1 reference

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A specificity-enhancing factor for the ClpXP degradation machine

25 May 2018

1 reference

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Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides

25 May 2018

1 reference

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The structures of HsIU and the ATP-dependent protease HsIU-HsIV

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes

25 May 2018

1 reference

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The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery.

25 May 2018

1 reference

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Engineering controllable protein degradation.

15 August 2018

1 reference

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Characterization of mutants of the Escherichia coli AAA protease, FtsH, carrying a mutation in the central pore region.

15 August 2018

1 reference

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Substrate specific consequences of central pore mutations in the i-AAA protease Yme1 on substrate engagement

15 August 2018

1 reference

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Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines

15 August 2018

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Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation

15 August 2018

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Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine.

15 August 2018

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Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase

15 August 2018

1 reference

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The molecular chaperone, ClpA, has a single high affinity peptide binding site per hexamer

15 August 2018

1 reference

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Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease.

15 August 2018

1 reference

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Substrate recognition by the AAA+ chaperone ClpB.

15 August 2018

1 reference

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Communication between ClpX and ClpP during substrate processing and degradation

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

Effects of local protein stability and the geometric position of the substrate degradation tag on the efficiency of ClpXP denaturation and degradation

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

Bivalent tethering of SspB to ClpXP is required for efficient substrate delivery: a protein-design study.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

Targeted Delivery of an ssrA-Tagged Substrate by the Adaptor Protein SspB to Its Cognate AAA+ Protein ClpX

15 August 2018

1 reference

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Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

Conserved Pore Residues in the AAA Protease FtsH Are Important for Proteolysis and Its Coupling to ATP Hydrolysis

15 August 2018

1 reference

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Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine.

15 August 2018

1 reference

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Energy-dependent degradation: Linkage between ClpX-catalyzed nucleotide hydrolysis and protein-substrate processing.

15 August 2018

1 reference

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Characterization of a specificity factor for an AAA+ ATPase: assembly of SspB dimers with ssrA-tagged proteins and the ClpX hexamer

15 August 2018

1 reference

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ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal

15 August 2018

1 reference

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Dynamics of substrate denaturation and translocation by the ClpXP degradation machine

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2323458

The N-terminal zinc binding domain of ClpX is a dimerization domain that modulates the chaperone function

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18313382

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Enzymatic and structural similarities between the Escherichia coli ATP-dependent proteases, ClpXP and ClpAP

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18313382

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2008.02.002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18313382%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18313382%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

18313382

1 reference