Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation (Q43565734)

24 November 2017

title

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation (English)

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24 November 2017

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1

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6

Haass C

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24 November 2017

Steiner B

2

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24 November 2017

Marques C

3

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24 November 2017

Leutz S

4

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24 November 2017

Romig H

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24 November 2017

Müller WE

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24 November 2017

language of work or name

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1 April 2001

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Journal of Neuroscience Research

24 November 2017

published in

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24 November 2017

volume

64

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24 November 2017

issue

2

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24 November 2017

page(s)

183-192

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beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease

24 November 2017

cites work

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease

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Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures

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Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

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Elevated levels of fragmented DNA nucleosomes in native and activated lymphocytes indicate an enhanced sensitivity to apoptosis in sporadic Alzheimer's disease. Specific differences to vascular dementia.

21 January 2018

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

21 January 2018

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Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation

21 January 2018

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

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Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons

21 January 2018

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A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

21 January 2018

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Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.

21 January 2018

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In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment

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The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

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Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

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Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation

21 January 2018

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Caspases find a new place to hide.

21 January 2018

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

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Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

21 January 2018

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Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

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21 January 2018

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Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

21 January 2018

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Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

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21 January 2018

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Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis

21 January 2018

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21 January 2018

Caspases: enemies within

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Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

21 January 2018

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Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

21 January 2018

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Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

21 January 2018

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Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis

21 January 2018

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G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

21 January 2018

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

21 January 2018

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The significance of the Swedish APP670/671 mutation for the development of Alzheimer's disease amyloidosis

21 January 2018

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Enhancing effect of manganese on L-DOPA-induced apoptosis in PC12 cells: role of oxidative stress

21 January 2018

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Comparison of the apoptotic pathways induced by L-amino acid oxidase and hydrogen peroxide

21 January 2018

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Altered processing of a mutant amyloid precursor protein in neuronal and endothelial cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JNR.1064

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24 November 2017

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