Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins (Q43670938)

25 November 2017

title

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins (English)

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25 November 2017

main subject

protein ubiquitination

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M Yokouchi

1

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25 November 2017

T Kondo

2

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25 November 2017

A Sanjay

3

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25 November 2017

A Houghton

4

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25 November 2017

A Yoshimura

5

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25 November 2017

S Komiya

6

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25 November 2017

H Zhang

7

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25 November 2017

R Baron

8

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25 November 2017

language of work or name

English

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publication date

11 July 2001

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Journal of Biological Chemistry

25 November 2017

published in

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25 November 2017

volume

276

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25 November 2017

issue

37

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25 November 2017

page(s)

35185-35193

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Phosphotyrosine Binding Domain-Dependent Upregulation of the Platelet-Derived Growth Factor Receptor α Signaling Cascade by Transforming Mutants of Cbl: Implications for Cbl’s Function and Oncogenicity

25 November 2017

cites work

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Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

21 January 2018

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Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway

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Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl

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Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

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The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

21 January 2018

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

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The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

21 January 2018

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 January 2018

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Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain

21 January 2018

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Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

21 January 2018

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

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RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation

21 January 2018

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Cbl: many adaptations to regulate protein tyrosine kinases

21 January 2018

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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

21 January 2018

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Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl. A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growth factor receptor

21 January 2018

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Regulating protein degradation by ubiquitination

21 January 2018

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The ubiquitin-proteasome pathway: on protein death and cell life

21 January 2018

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21 January 2018

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Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels

21 January 2018

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Themes and variations on ubiquitylation

21 January 2018

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Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

21 January 2018

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Cellular functions regulated by Src family kinases

21 January 2018

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Selected glimpses into the activation and function of Src kinase

21 January 2018

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Three-dimensional structure of the tyrosine kinase c-Src

21 January 2018

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

21 January 2018

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Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

21 January 2018

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Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

21 January 2018

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Ubiquitin-dependent degradation of active Src.

21 January 2018

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Ubiquitin-mediated degradation of active Src tyrosine kinase

21 January 2018

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c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

21 January 2018

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Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

21 January 2018

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 January 2018

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Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

21 January 2018

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Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

21 January 2018

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The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation

21 January 2018

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

21 January 2018

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RING domains: master builders of molecular scaffolds?

21 January 2018

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

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21 January 2018

RING for destruction?

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Recognition and specificity in protein tyrosine kinase-mediated signalling

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M102219200

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25 November 2017

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