Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells (Q43800235)

26 November 2017

title

Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells (English)

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26 November 2017

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K Koniaras

1

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26 November 2017

A R Cuddihy

2

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26 November 2017

H Christopoulos

3

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26 November 2017

A Hogg

4

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26 November 2017

M J O'Connell

5

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26 November 2017

language of work or name

English

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publication date

1 November 2001

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26 November 2017

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26 November 2017

volume

20

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26 November 2017

issue

51

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26 November 2017

page(s)

7453-7463

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The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells

26 November 2017

cites work

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Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity

21 January 2018

1 reference

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

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Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase

21 January 2018

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

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Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.

21 January 2018

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The decision to enter mitosis

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Cell cycle checkpoints: preventing an identity crisis

21 January 2018

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

21 January 2018

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Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

21 January 2018

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Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase

21 January 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

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Development of a bicistronic vector driven by the human polypeptide chain elongation factor 1alpha promoter for creation of stable mammalian cell lines that express very high levels of recombinant proteins

21 January 2018

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Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

21 January 2018

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Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells

21 January 2018

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ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

1 reference

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The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts

21 January 2018

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Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

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Genetic instabilities in human cancers

21 January 2018

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The pachytene checkpoint in S. cerevisiae depends on Swe1-mediated phosphorylation of the cyclin-dependent kinase Cdc28.

21 January 2018

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p53, the cellular gatekeeper for growth and division

21 January 2018

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The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

21 January 2018

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

21 January 2018

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Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Wee1.

21 January 2018

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Universal control mechanism regulating onset of M-phase

21 January 2018

1 reference

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Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204942

The G2-phase DNA-damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204942

Regulation of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204942

Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage

21 January 2018

1 reference

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Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast

21 January 2018

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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

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Absence of p53-dependent cell cycle regulation in pluripotent mouse cell lines

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

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Regulation of the G2/M transition by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204942

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204942

Life, death, and the pursuit of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204942

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204942

Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204942

inferred from DOI database lookup

7 January 2021

based on heuristic

Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204942

inferred from DOI database lookup

7 January 2021

based on heuristic

Premature chromatin condensation upon accumulation of NIMA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204942

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1204942

1 reference

Dimensions Publication ID

26 November 2017

1031175576

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1 reference