Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state. (Q43995088)

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English	Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state.	scientific article

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28 February 2020

Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state (English)

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28 February 2020

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Dmytro V Vasylyev

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Fadia Dib-Hajj

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Krishna R Veeramah

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Michael F Hammer

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Sulayman D Dib-Hajj

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Stephen G Waxman

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1 October 2013

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28 February 2020

Journal of Neuroscience

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16586-16593

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28 February 2020

The eag family of K+ channels in Drosophila and mammals

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https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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Cloning of components of a novel subthreshold-activating K(+) channel with a unique pattern of expression in the cerebral cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and functional expression of rat eag2, a new member of the ether-à-go-go family of potassium channels and comparison of its distribution with that of eag1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mg(2+) modulates voltage-dependent activation in ether-à-go-go potassium channels by binding between transmembrane segments S2 and S3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ion channels and epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional distinction of human EAG1 and EAG2 potassium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular identification and characterisation of the human eag2 potassium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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Ether à go-go potassium channels and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

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Potassium channels as tumour markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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Overexpression of Eag1 potassium channels in clinical tumours.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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Ether à go-go potassium channel expression in soft tissue sarcoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Closing in on the resting state of the Shaker K(+) channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein structure homology modeling using SWISS-MODEL workspace.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divalent cations slow activation of EAG family K+ channels through direct binding to S4

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Voltage-gated potassium channels as therapeutic targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NaV1.1 channels and epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Gating Charge Transfer Center in Voltage Sensors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis and structural insight of vascular K(ATP) channel gating by S-glutathionylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contributions of counter-charge in a potassium channel voltage-sensor domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting BK (big potassium) channels in epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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Structural basis for gating charge movement in the voltage sensor of a sodium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of voltage gating in potassium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

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Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of K(v)7.2 potassium channel subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular architecture of a sodium channel S6 helix: radial tuning of the voltage-gated sodium channel 1.7 activation gate

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exome sequencing reveals new causal mutations in children with epileptic encephalopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular Mg2+ regulates activation of rat eag potassium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Drosophila erg K+ channel polypeptide is encoded by the seizure locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The seizure locus encodes the Drosophila homolog of the HERG potassium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/24133262

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2307-13.2013

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28 February 2020

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28 February 2020

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