Refocusing Neuroprotection in Cerebral Reperfusion Era: New Challenges and Strategies. (Q54967560)

14 June 2018

title

Refocusing Neuroprotection in Cerebral Reperfusion Era: New Challenges and Strategies. (English)

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14 June 2018

author name string

Xiao-Yi Xiong

series ordinal

1

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14 June 2018

Liang Liu

series ordinal

2

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14 June 2018

Qing-Wu Yang

series ordinal

3

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14 June 2018

publication date

23 April 2018

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14 June 2018

published in

Frontiers in Neurology

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14 June 2018

volume

9

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14 June 2018

page(s)

249

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14 June 2018

Preclinical randomized controlled multicenter trials (pRCT) in stroke research: a new and valid approach to improve translation?

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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Head position and cerebral blood flow velocity in acute ischemic stroke: a systematic review and meta-analysis

16 June 2018

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Time to angiographic reperfusion and clinical outcome after acute ischaemic stroke: an analysis of data from the Interventional Management of Stroke (IMS III) phase 3 trial

16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia

16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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16 June 2018

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Mechanisms, challenges and opportunities in stroke

16 June 2018

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Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

16 June 2018

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Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

16 June 2018

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Recommendations for standards regarding preclinical neuroprotective and restorative drug development

16 June 2018

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Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence.

16 June 2018

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Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment

16 June 2018

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Cerebral ischemia. II. The no-reflow phenomenon

16 June 2018

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Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons

16 June 2018

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Potential of Stem Cell-Based Therapy for Ischemic Stroke.

16 June 2018

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Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice.

13 August 2018

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N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway

13 August 2018

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Extending the Time Window for Endovascular and Pharmacological Reperfusion.

13 August 2018

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Developing New Stroke Treatments Using Preclinical Randomized Controlled Trials

13 August 2018

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Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial.

13 August 2018

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Endovascular therapy of 623 patients with anterior circulation stroke.

13 August 2018

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CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke.

13 August 2018

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Extending the time window for endovascular procedures according to collateral pial circulation.

13 August 2018

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Effect of baseline CT scan appearance and time to recanalization on clinical outcomes in endovascular thrombectomy of acute ischemic strokes

13 August 2018

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Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Sildenafil treatment of subacute ischemic stroke: a safety study at 25-mg daily for 2 weeks

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Enhanced angiogenesis with dl-3n-butylphthalide treatment after focal cerebral ischemia in RHRSP.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET).

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Heads down: flat positioning improves blood flow velocity in acute ischemic stroke

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Effects of the spin trap agent disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) on intracerebral hemorrhage in a rabbit Large clot embolic stroke model: combination studies with tissue plasminogen activator

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5926527

Comparison of Neurological Scales and Scoring Systems for Acute Stroke Prognosis

13 August 2018

1 reference

12 December 2020

tPA and proteolysis in the neurovascular unit

1 reference

12 December 2020

Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration

1 reference

12 December 2020

NXY-059 for the treatment of acute ischemic stroke

1 reference

12 December 2020

Stroke treatment--light at the end of the tunnel?

1 reference

12 December 2020

Effect of Time to Reperfusion on Clinical Outcome of Anterior Circulation Strokes Treated With Thrombectomy

1 reference

12 December 2020

Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury

1 reference

12 December 2020

Identifiers

DOI

10.3389/FNEUR.2018.00249

1 reference

14 June 2018

PMC publication ID

5926527

1 reference

14 June 2018

PubMed publication ID

29740385

1 reference

14 June 2018