TSE agent strains and PrP: reconciling structure and function. (Q55036247)

16 June 2018

title

TSE agent strains and PrP: reconciling structure and function. (English)

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16 June 2018

author name string

Robert A Somerville

series ordinal

1

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16 June 2018

publication date

1 December 2002

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16 June 2018

number of pages

7

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Trends in Biochemical Sciences

inferred from page(s)

published in

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16 June 2018

volume

27

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16 June 2018

issue

12

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16 June 2018

page(s)

606-612

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16 June 2018

Novel proteinaceous infectious particles cause scrapie

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Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

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Changing a single amino acid in the N-terminus of murine PrP alters TSE incubation time across three species barriers

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A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy

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Protease-resistant and detergent-insoluble prion protein is not necessarily associated with prion infectivity

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Scrapie infectivity is independent of amyloid staining properties of the N-terminally truncated prion protein

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Characterization of thermodynamic diversity between transmissible spongiform encephalopathy agent strains and its theoretical implications

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Protease-resistant prion protein produced in vitro lacks detectable infectivity.

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Scrapie infectivity correlates with converting activity, protease resistance, and aggregation of scrapie-associated prion protein in guanidine denaturation studies.

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Scrapie infectious agent is virus-like in size and susceptibility to inactivation

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Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier

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Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

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7 January 2021

Spontaneous neurodegeneration in transgenic mice with mutant prion protein

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7 January 2021

Scrapie agent: prions or virinos?

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7 January 2021

MicroRNAs: deviants no longer.

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The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice

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7 January 2021

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Identifiers

DOI

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16 June 2018

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16 June 2018