The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection (Q57029697)

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23 April 2020

title

The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection (English)

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23 April 2020

author name string

David Billing

1

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23 April 2020

Michiko Horiguchi

2

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23 April 2020

Foon Wu-Baer

3

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23 April 2020

Angelo Taglialatela

4

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23 April 2020

Silvia Alvarez Nanez

6

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23 April 2020

Wenxia Jiang

7

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23 April 2020

Matthias Szabolcs

9

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23 April 2020

Chyuan-Sheng Lin

10

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23 April 2020

Alberto Ciccia

11

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23 April 2020

Richard Baer

12

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23 April 2020

language of work or name

English

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publication date

20 September 2018

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23 April 2020

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23 April 2020

volume

72

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issue

1

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23 April 2020

page(s)

127-139.e8

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describes a project that uses

23 April 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1 reference

12 December 2020

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

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12 December 2020

Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains

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12 December 2020

Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein

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12 December 2020

Brca1 controls homology-directed DNA repair

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12 December 2020

Tumorigenesis in mice carrying a truncating Brca1 mutation

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12 December 2020

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

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12 December 2020

Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability

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12 December 2020

BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks

1 reference

12 December 2020

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

1 reference

12 December 2020

The BRCT Domain Is a Phospho-Protein Binding Domain

1 reference

12 December 2020

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

1 reference

12 December 2020

Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling

1 reference

12 December 2020

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

1 reference

12 December 2020

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.

1 reference

12 December 2020

Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains

1 reference

12 December 2020

Interactions between BRCT repeats and phosphoproteins: tangled up in two

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12 December 2020

Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.

1 reference

12 December 2020

Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks

1 reference

12 December 2020

Crystal structure of the BARD1 BRCT domains

1 reference

12 December 2020

Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair

1 reference

12 December 2020

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex

1 reference

12 December 2020

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

1 reference

12 December 2020

The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.

1 reference

12 December 2020

Inherited susceptibility to common cancers

1 reference

12 December 2020

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

1 reference

12 December 2020

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

1 reference

12 December 2020

A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage

1 reference

12 December 2020

Preclinical mouse models for BRCA1-associated breast cancer

1 reference

12 December 2020

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

1 reference

12 December 2020

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

1 reference

12 December 2020

Cancer predisposing BARD1 mutations in breast-ovarian cancer families

1 reference

12 December 2020

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

1 reference

12 December 2020

Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

1 reference

12 December 2020

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

1 reference

12 December 2020

Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA.

1 reference

12 December 2020

Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1

1 reference

12 December 2020

Evolutionary pathways in BRCA1-associated breast tumors

1 reference

12 December 2020

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

1 reference

12 December 2020

Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation

1 reference

12 December 2020

Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.

1 reference

12 December 2020

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks

1 reference

12 December 2020

BRCA1 haploinsufficiency for replication stress suppression in primary cells

1 reference

12 December 2020

Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

1 reference

12 December 2020

Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif

1 reference

12 December 2020

Frequent incidence of BARD1-truncating mutations in germline DNA from triple-negative breast cancer patients

1 reference

12 December 2020

Deciphering the BRCA1 Tumor Suppressor Network

1 reference

12 December 2020

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.

1 reference

12 December 2020

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.

1 reference

12 December 2020

Replication fork stability confers chemoresistance in BRCA-deficient cells

1 reference

12 December 2020

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.

1 reference

12 December 2020

Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.

1 reference

12 December 2020

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

1 reference

12 December 2020

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

1 reference

12 December 2020

Replication fork reversal triggers fork degradation in BRCA2-defective cells

1 reference

12 December 2020

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.

1 reference

12 December 2020

10.1016/J.MOLCEL.2018.08.016

Identifiers

DOI

1 reference

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23 April 2020

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23 April 2020

PubMed publication ID

30244837

1 reference