TCR affinity and negative regulation limit autoimmunity (Q57184989)

12

Nicholas R J Gascoigne

0 references

Elissa K. Deenick

Elissa K Deenick

7

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Awen Gallimore

Awen Gallimore

11

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Pamela Ohashi

Pamela S Ohashi

13

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Josef Penninger

Josef M Penninger

9

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author name string

Matthew A Gronski

1

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Jonathan M Boulter

2

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Demetrius Moskophidis

3

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Linh T Nguyen

4

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Kaisa Holmberg

5

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Alisha R Elford

6

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Hee O Kim

8

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Bernhard Odermatt

Structural basis of molecular mimicry

10

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language of work or name

English

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publication date

3 October 2004

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published in

Nature Medicine

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volume

10

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issue

11

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page(s)

1234-1239

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cites work

1 reference

Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?

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Cbl-b regulates the CD28 dependence of T-cell activation.

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Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein

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Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection.

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Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis

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Functional activation of myelin-specific T cells by virus-induced molecular mimicry

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A functional and structural basis for TCR cross-reactivity in multiple sclerosis

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Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

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Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

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CDR3 loop flexibility contributes to the degeneracy of TCR recognition

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1 reference

Mimicking the way to autoimmunity: an evolving theory of sequence and structural homology

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1 reference

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness

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1 reference

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

21 January 2018

1 reference

T-cell-receptor affinity and thymocyte positive selection

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1 reference

Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex

21 January 2018

1 reference

Virus-induced diabetes in a transgenic model: role of cross-reacting viruses and quantitation of effector T cells needed to cause disease

21 January 2018

1 reference

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

21 January 2018

1 reference

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

21 January 2018

1 reference

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

21 January 2018

1 reference

Stable, soluble T-cell receptor molecules for crystallization and therapeutics

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1 reference

Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance

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Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

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1 reference

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

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1 reference

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

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1 reference

7 January 2021

T-cell receptor binding kinetics in T-cell development and activation

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7 January 2021

A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses

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7 January 2021

TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR

1 reference

7 January 2021

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

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7 January 2021

Emergence of virus escape mutants after immunization with epitope vaccine.

1 reference

7 January 2021

Cblb is a major susceptibility gene for rat type 1 diabetes mellitus

1 reference

7 January 2021

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism

1 reference

7 January 2021

TCR binding to peptide-MHC stabilizes a flexible recognition interface

1 reference

7 January 2021