Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis (Q58053853)

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English	Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis	article

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scholarly article

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Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis (English)

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papillary thyroid cancer

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based on heuristic

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Raffaele Ciampi

object named as

Raffaele Ciampi

8

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Gerard M Doherty

object named as

Gerard Doherty

12

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Thomas Giordano

object named as

Thomas J Giordano

1

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author name string

Rork Kuick

2

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Dafydd G Thomas

3

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David E Misek

4

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Michelle Vinco

5

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Donita Sanders

6

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Zhaowen Zhu

7

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Michael Roh

9

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Kerby Shedden

10

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Paul Gauger

11

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Norman W Thompson

13

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Samir Hanash

14

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Ronald J Koenig

15

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Yuri E Nikiforov

16

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language of work or name

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publication date

27 June 2005

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24

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44

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6646-6656

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Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes

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The genetics and genomics of cancer

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Ras oncogene mutations in thyroid tumors: polymerase chain reaction-restriction-fragment-length polymorphism analysis from paraffin-embedded tissues.

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Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2).

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Profiling cancer

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Gene expression in papillary thyroid carcinoma reveals highly consistent profiles

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A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 [see commetns]

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Well differentiated thyroid carcinoma

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Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma.

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Design and discovery of small molecules targeting raf-1 kinase

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Discovery of a novel Raf kinase inhibitor

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Chronic expression of RET/PTC 3 enhances basal and insulin-stimulated PI3 kinase/AKT signaling and increases IRS-2 expression in FRTL-5 thyroid cells

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Molecular pathogenesis of thyroid nodules and cancer

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Point mutations of ras oncogenes are an early event in thyroid tumorigenesis

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RET/PTC rearrangement in thyroid tumors

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BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas

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Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

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Asymptotics for and against cross-validation

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Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer.

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10.1038/SJ.ONC.1208822

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