Ezrin mediates growth and survival in Ewing’s sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway (Q58376176)

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scientific article published on 22 September 2006

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English	Ezrin mediates growth and survival in Ewing’s sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway	scientific article published on 22 September 2006

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Europe PubMed Central

PubMed publication ID

17028919

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

title

Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway (English)

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stated in

Europe PubMed Central

PubMed publication ID

17028919

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

author

Stephen M. Hewitt

series ordinal

3

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Europe PubMed Central

PubMed publication ID

17028919

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

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20 December 2019

author name string

Kartik Krishnan

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1

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Europe PubMed Central

PubMed publication ID

17028919

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

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20 December 2019

Ben Bruce

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2

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PubMed publication ID

17028919

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

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20 December 2019

Dafydd Thomas

series ordinal

4

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Europe PubMed Central

PubMed publication ID

17028919

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

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20 December 2019

Chand Khanna

series ordinal

5

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stated in

Europe PubMed Central

PubMed publication ID

17028919

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

Lee J Helman

series ordinal

6

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stated in

Europe PubMed Central

PubMed publication ID

17028919

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

publication date

22 September 2006

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stated in

Europe PubMed Central

PubMed publication ID

17028919

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

published in

Clinical & Experimental Metastasis

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stated in

Europe PubMed Central

PubMed publication ID

17028919

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

volume

23

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Europe PubMed Central

PubMed publication ID

17028919

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

issue

3-4

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Europe PubMed Central

PubMed publication ID

17028919

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

page(s)

227-236

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Europe PubMed Central

PubMed publication ID

17028919

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

cites work

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide 3-hydroxide kinase blockade enhances apoptosis in the Ewing's sarcoma family of tumors.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane-actin microfilament connections: an increasing diversity of players related to band 4.1.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

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inferred from PubMed ID database lookup

CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ewing's sarcoma; a study of fifty cases treated at the Massachusetts General Hospital, 1930-1952 inclusive

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent phagocytic activity discriminates metastatic and primary human malignant melanomas: a key role of ezrin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/beta-catenin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The TOR pathway: a target for cancer therapy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous expression of Fas and nonfunctional Fas ligand in Ewing's sarcoma

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic pathways implicated in ovarian epithelial cancer

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-terminal threonine phosphorylation activates ERM proteins to link the cell's cortical lipid bilayer to the cytoskeleton

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, construction, and use of tissue microarrays

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ezrin in primary cutaneous melanoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the PKB/AKT pathway by ICAM-2.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biology of metastases in pediatric sarcomas

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Merlin and ERM proteins: unappreciated roles in cancer development?

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of circulating tumor cells in patients with Ewing's sarcoma and peripheral primitive neuroectodermal tumor

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17028919

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S10585-006-9033-Y

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17028919

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

PubMed publication ID

17028919

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17028919

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17028919%20AND%20SRC:MED&resulttype=core&format=json

retrieved

20 December 2019

 

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