Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening (Q59125760)

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scientific article published on 02 November 2018

Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening

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English	Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening	scientific article published on 02 November 2018	Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening

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scholarly article

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Identification of new inhibitors of Mdm2-p53 interaction via pharmacophore and structure-based virtual screening (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

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virtual screening

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based on heuristic

inferred from title

1

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

Mohammad A Ghattas

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

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Sara Al Rawashdeh

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

Mohammad Al Sorkhy

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

Sanaa K Bardaweel

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

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publication date

November 2018

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12

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Drug Design, Development and Therapy

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

12

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

3741-3752

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

copyright license

Creative Commons Attribution-NonCommercial 3.0 Unported

1 November 2018

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April 2022 Public Data File from Crossref

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How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures.

1 reference

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30 November 2018

Analysis of Enoyl-Acyl Carrier Protein Reductase Structure and Interactions Yields an Efficient Virtual Screening Approach and Suggests a Potential Allosteric Site.

1 reference

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30 November 2018

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode

1 reference

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30 November 2018

p53: its mutations and their impact on transcription

1 reference

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30 November 2018

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30 November 2018

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction

1 reference

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30 November 2018

Protein tyrosine phosphatases: Ligand interaction analysis and optimisation of virtual screening

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30 November 2018

Unravelling mechanisms of p53-mediated tumour suppression

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30 November 2018

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction

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30 November 2018

Targeting apoptosis pathways for new cancer therapeutics.

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30 November 2018

Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development

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30 November 2018

Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors

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30 November 2018

Rational design and binding mode duality of MDM2-p53 inhibitors

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p53 mutations in cancer

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Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils

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30 November 2018

Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists

1 reference

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30 November 2018

Translational approaches targeting the p53 pathway for anti-cancer therapy

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30 November 2018

MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells

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30 November 2018

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

1 reference

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30 November 2018

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

1 reference

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30 November 2018

Therapeutic targeting of p53 by small molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6223338

30 November 2018

Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction

1 reference

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30 November 2018

When mutants gain new powers: news from the mutant p53 field.

1 reference

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30 November 2018

Mutant p53 targeting by the low molecular weight compound STIMA-1

1 reference

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30 November 2018

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

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p53 in health and disease

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Targeting the p53-MDM2 interaction to treat cancer

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Dynamics of the p53-Mdm2 feedback loop in individual cells

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.2147/DDDT.S182444

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30464405%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

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