Targeting p53-dependent stem cell loss for intestinal chemoprotection. (Q50045903)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29437148%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

title

Targeting p53-dependent stem cell loss for intestinal chemoprotection (English)

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16 March 2020

7

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16 March 2020

Brian J Leibowitz

1

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16 March 2020

Liheng Yang

2

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16 March 2020

Liang Wei

3

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16 March 2020

Monica E Buchanan

4

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16 March 2020

Robert A Parise

6

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16 March 2020

Robert E Schoen

9

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16 March 2020

Lin Zhang

10

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16 March 2020

Jian Yu

11

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16 March 2020

author name string

Madani Rachid

5

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16 March 2020

Julie L Eiseman

8

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16 March 2020

language of work or name

English

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publication date

1 February 2018

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Science Translational Medicine

16 March 2020

published in

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16 March 2020

volume

10

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16 March 2020

issue

427

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Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice

16 March 2020

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26 August 2018

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26 August 2018

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26 August 2018

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Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory?

26 August 2018

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Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.

26 August 2018

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Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management

26 August 2018

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PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.

26 August 2018

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p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis

26 August 2018

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PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.

26 August 2018

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Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.

26 August 2018

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Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death

26 August 2018

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Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis

26 August 2018

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Characterization of the Intestinal Cancer Stem Cell Marker CD166 in the Human and Mouse Gastrointestinal Tract

26 August 2018

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Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.

26 August 2018

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Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

26 August 2018

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Pathologies associated with the p53 response

26 August 2018

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Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.

26 August 2018

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p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

26 August 2018

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Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.

26 August 2018

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PUMA, a potent killer with or without p53

26 August 2018

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PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis

26 August 2018

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Blinded by the Light: The Growing Complexity of p53

26 August 2018

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PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

26 August 2018

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Chemosensitization of head and neck cancer cells by PUMA

26 August 2018

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Tracking down the stem cells of the intestine: strategies to identify adult stem cells

26 August 2018

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Identification of stem cells in small intestine and colon by marker gene Lgr5

26 August 2018

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The Bcl-2 apoptotic switch in cancer development and therapy

26 August 2018

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Role of p53 in irinotecan-induced intestinal cell death and mucosal damage

26 August 2018

1 reference

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p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5827930

PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5827930

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5827930

The transcriptional targets of p53 in apoptosis control

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5827930

Cancer genes and the pathways they control

26 August 2018

1 reference

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Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

26 August 2018

1 reference

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

26 August 2018

1 reference

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

26 August 2018

1 reference

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PUMA mediates the apoptotic response to p53 in colorectal cancer cells

26 August 2018

1 reference

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PUMA induces the rapid apoptosis of colorectal cancer cells

26 August 2018

1 reference

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Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans

26 August 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

26 August 2018

1 reference

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Wild-type p53 differentially affects tumorigenic and metastatic potential of murine metastatic cell variants

26 August 2018

1 reference

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Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11.

26 August 2018

1 reference

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Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors

26 August 2018

1 reference

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

26 August 2018

1 reference

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Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11

26 August 2018

1 reference

12 December 2020

Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats

1 reference

12 December 2020

Experimental antitumor activity and pharmacokinetics of the camptothecin analog irinotecan (CPT-11) in mice

1 reference

12 December 2020

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

1 reference

12 December 2020

10.1126/SCITRANSLMED.AAM7610

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29437148%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29437148%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

PubMed publication ID

29437148

1 reference