A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. (Q51059487)

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scientific article published in April 2010

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English	A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.	scientific article published in April 2010

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30 January 2020

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo (English)

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30 January 2020

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30 January 2020

William L. Klein

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William L Klein

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30 January 2020

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Takami Tomiyama

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Shogo Matsuyama

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30 January 2020

Hiroyuki Iso

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30 January 2020

Tomohiro Umeda

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30 January 2020

Hiroshi Takuma

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30 January 2020

Kiyouhisa Ohnishi

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Kenichi Ishibashi

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Rie Teraoka

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Naomi Sakama

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30 January 2020

Takenari Yamashita

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30 January 2020

Kazuchika Nishitsuji

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30 January 2020

Hiroyuki Shimada

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30 January 2020

Mary P Lambert

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30 January 2020

Hiroshi Mori

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30 January 2020

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1 April 2010

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30 January 2020

Journal of Neuroscience

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30 January 2020

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30 January 2020

14

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30 January 2020

4845-4856

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30 January 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6632783/fullTextXML

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

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Deposition of beta-amyloid subtypes 40 and 42 differentiates dementia with Lewy bodies from Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

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Intraneuronal Abeta42 accumulation in human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

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12 December 2020

based on heuristic

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Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

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12 December 2020

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Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Alzheimer's disease is a synaptic failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Intraneuronal Abeta42 accumulation in Down syndrome brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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APP processing and synaptic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

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NeuN, a neuronal specific nuclear protein in vertebrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Intra- and extracellular Abeta and PHF in clinically evaluated cases of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

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Neurodegeneration and plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

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Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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A dynamic relationship between intracellular and extracellular pools of Abeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Absence of synaptophysin near cortical neurons containing oligomer Abeta in Alzheimer's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Monoclonal antibodies that target pathological assemblies of Abeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

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Environmental change during postnatal development alters behaviour, cognitions and neurogenesis of mice

1 reference

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12 December 2020

based on heuristic

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Congo red and thioflavin-T analogs detect Abeta oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20371804

12 December 2020

based on heuristic

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Alzheimer disease models and human neuropathology: similarities and differences

1 reference

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A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

1 reference

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12 December 2020

based on heuristic

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Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices

1 reference

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12 December 2020

based on heuristic

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Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease

1 reference

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12 December 2020

based on heuristic

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

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12 December 2020

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Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.

1 reference

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The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells

1 reference

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based on heuristic

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A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage

1 reference

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12 December 2020

based on heuristic

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

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based on heuristic

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A vector for expressing foreign genes in the brains and hearts of transgenic mice

1 reference

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based on heuristic

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Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.

1 reference

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based on heuristic

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Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

1 reference

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

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Identifiers

10.1523/JNEUROSCI.5825-09.2010

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30 January 2020

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24 November 2022

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30 January 2020

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30 January 2020

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