Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. (Q51953017)

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scientific article published on 6 July 2008

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English	Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.	scientific article published on 6 July 2008

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Europe PubMed Central

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18604206

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18 April 2018

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http://europepmc.org/abstract/MED/18604206

title

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. (English)

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18604206

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18 April 2018

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author

Manfred Gessler

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Manfred Gessler

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6

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Evelyne Fischer

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Evelyne Fischer

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3

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Helen McNeill

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Helen McNeill

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10

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Sakura Saburi

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1

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18604206

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18 April 2018

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Ian Hester

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2

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18604206

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Marco Pontoglio

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4

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18604206

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Vera Eremina

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5

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18604206

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18 April 2018

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Sue E Quaggin

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7

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18604206

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Robert Harrison

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8

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Richard Mount

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9

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18604206

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http://europepmc.org/abstract/MED/18604206

language of work or name

English

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publication date

6 July 2008

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18604206

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18 April 2018

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http://europepmc.org/abstract/MED/18604206

published in

Nature Genetics

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18604206

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18 April 2018

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http://europepmc.org/abstract/MED/18604206

volume

40

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18604206

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18 April 2018

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http://europepmc.org/abstract/MED/18604206

issue

8

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18604206

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18 April 2018

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http://europepmc.org/abstract/MED/18604206

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1010-1015

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cites work

Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility

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Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse

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Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling

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The cadherins fat and dachsous regulate dorsal/ventral signaling in the Drosophila eye.

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The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.

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Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression

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Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

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Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

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Fidelity in planar cell polarity signalling.

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7 January 2021

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Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity

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Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

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Planar cell polarity signaling in vertebrates

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https://api.crossref.org/works/10.1038%2FNG.179

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7 January 2021

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The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells

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7 January 2021

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Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation

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7 January 2021

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The orientation of cell divisions determines the shape of Drosophila organs.

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Defective planar cell polarity in polycystic kidney disease

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7 January 2021

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The rodent Four-jointed ortholog Fjx1 regulates dendrite extension

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Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

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https://api.crossref.org/works/10.1038%2FNG.179

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7 January 2021

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Role of primary cilia in the pathogenesis of polycystic kidney disease

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https://api.crossref.org/works/10.1038%2FNG.179

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7 January 2021

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Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease?

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Crossref

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https://api.crossref.org/works/10.1038%2FNG.179

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7 January 2021

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Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.

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Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases

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https://api.crossref.org/works/10.1038%2FNG.179

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Polycystic kidney disease: cell division without a c(l)ue?

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7 January 2021

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Identifiers

DOI

10.1038/NG.179

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18604206

retrieved

18 April 2018

reference URL

http://europepmc.org/abstract/MED/18604206

PubMed publication ID

18604206

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18604206

retrieved

18 April 2018

reference URL

http://europepmc.org/abstract/MED/18604206

ResearchGate publication ID

5247216

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