Phase I trial of 7-hydroxystaurosporine and fludararbine phosphate: in vivo evidence of 7-hydroxystaurosporine induced apoptosis in chronic lymphocytic leukemia. (Q53234212)

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scientific article published on 12 July 2011

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English	Phase I trial of 7-hydroxystaurosporine and fludararbine phosphate: in vivo evidence of 7-hydroxystaurosporine induced apoptosis in chronic lymphocytic leukemia.	scientific article published on 12 July 2011

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scholarly article

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7 February 2020

Phase I trial of 7-hydroxystaurosporine and fludararbine phosphate: in vivo evidence of 7-hydroxystaurosporine induced apoptosis in chronic lymphocytic leukemia (English)

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7 February 2020

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phase I clinical trial

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based on heuristic

inferred from title

7

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7 February 2020

Maryalice Stetler-Stevenson

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Maryalice Stetler-Stevenson

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7 February 2020

Wyndham H. Wilson

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Wyndham H Wilson

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7 February 2020

Kieron Dunleavy

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Kieron Dunleavy

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7 February 2020

Seth M Steinberg

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Seth M Steinberg

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7 February 2020

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Therese White

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7 February 2020

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Gerald E Marti

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7 February 2020

Nicole Drbohlav Grant

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7 February 2020

William D Figg

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7 February 2020

Tanyifor Tohnya

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7 February 2020

John E Janik

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7 February 2020

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12 July 2011

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7 February 2020

Leukemia & Lymphoma

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7 February 2020

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7 February 2020

12

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7 February 2020

2284-2292

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7 February 2020

Targeting checkpoint kinase 1 in cancer therapeutics

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Physiological modeling of altered pharmacokinetics of a novel anticancer drug, UCN-01 (7-hydroxystaurosporine), caused by slow dissociation of UCN-01 from human alpha1-acid glycoprotein.

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21 January 2018

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1 reference

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21 January 2018

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UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Effects of alpha1-acid glycoprotein on the clinical pharmacokinetics of 7-hydroxystaurosporine

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Acute tumour lysis syndrome after oral fludarabine in a patient with chronic lymphocytic leukaemia

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Tumor lysis syndrome associated with fludarabine treatment in chronic lymphocytic leukemia

1 reference

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21 January 2018

Tumor lysis syndrome (TLS) following fludarabine therapy for chronic lymphocytic leukemia (CLL): case report and review of the literature

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Variables in the quantification of CD4 in normals and hairy cell leukemia patients

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Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

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21 January 2018

Altered pharmacokinetics of a novel anticancer drug, UCN-01, caused by specific high affinity binding to alpha1-acid glycoprotein in humans

1 reference

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12 December 2020

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UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

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Phase II trial of fludarabine phosphate in lymphoma: an effective new agent in low-grade lymphoma

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12 December 2020

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inferred from PubMed ID database lookup

A phase I and pharmacokinetic study of short infusions of UCN-01 in patients with refractory solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fludarabine phosphate in the treatment of chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

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A loading dose/continuous infusion schedule of fludarabine phosphate in chronic lymphocytic leukemia

1 reference

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1 reference

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1 reference

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The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulation

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Fludarabine single-agent therapy for relapsed low-grade non-Hodgkin's lymphomas: a phase II study of the German Low-Grade Non-Hodgkin's Lymphoma Study Group

1 reference

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12 December 2020

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Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2

1 reference

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Tumor lysis syndrome: an uncommon complication of fludarabine therapy of chronic lymphocytic leukemia

1 reference

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inferred from PubMed ID database lookup

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10.3109/10428194.2011.589547

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21745173%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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7 February 2020

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7 February 2020

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