Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. (Q53659254)

16 May 2018

title

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15. (English)

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16 May 2018

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Renier J Brentjens

1

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16 May 2018

Jean-Baptiste Latouche

2

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16 May 2018

Elmer Santos

3

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Francesc Marti

4

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Michael C Gong

5

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Clay Lyddane

6

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Philip D King

7

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Steven Larson

8

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Mark Weiss

9

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Isabelle Rivière

10

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Michel Sadelain

11

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16 May 2018

language of work or name

English

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publication date

10 February 2003

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16 May 2018

published in

Nature Medicine

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16 May 2018

volume

9

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issue

3

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16 May 2018

page(s)

279-286

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16 May 2018

Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation

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IL-15 and IL-2: a matter of life and death for T cells in vivo

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Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

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Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo

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Cytokines and cell surface molecules independently induce CXCR4 expression on CD4+ CCR7+ human memory T cells.

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Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

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Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically modified activated human primary T lymphocytes

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Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes.

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Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule

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Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

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Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity

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The internal ribosomal entry site of the encephalomyocarditis virus enables reliable coexpression of two transgenes in human primary T lymphocytes

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Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells

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Ex vivo cell labeling with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomography

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Identifiers

DOI

10.1038/NM827

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16 May 2018

Dimensions Publication ID

1046693307

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16 May 2018