FKBP Ligands-Where We Are and Where to Go? (Q60046468)

1

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Andreas M Voll

2

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Michael Bauder

3

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Felix Hausch

Frontiers in Pharmacology

4

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language of work or name

English

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publication date

2018

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published in

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volume

9

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page(s)

1425

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copyright license

Creative Commons Attribution 4.0 International

start time

5 December 2018

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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12 December 2020

cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein

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12 December 2020

Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25

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Pathologic observations in human allograft recipients treated with FK 506

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Conversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications

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Liver, kidney, and thoracic organ transplantation under FK 506.

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A clinical trial of FK 506 as primary and rescue immunosuppression in cardiac transplantation

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Kidney transplantation under FK 506 immunosuppression

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Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

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Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13

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12 December 2020

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

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12 December 2020

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

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12 December 2020

A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection

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12 December 2020

Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

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12 December 2020

Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum

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12 December 2020

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

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12 December 2020

Signal transduction in T lymphocytes using a conditional allele of Sos

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12 December 2020

Immunophilins and nervous system

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12 December 2020

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

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12 December 2020

Controlling Signal Transduction with Synthetic Ligands

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12 December 2020

Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum

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12 December 2020

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

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12 December 2020

Selective binding of FKBP12.6 by the cardiac ryanodine receptor

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12 December 2020

Dimeric ligands define a role for transcriptional activation domains in reinitiation

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12 December 2020

Cellular functions of immunophilins

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12 December 2020

A humanized system for pharmacologic control of gene expression

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12 December 2020

Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506.

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12 December 2020

A three-hybrid system for detecting small ligand-protein receptor interactions

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12 December 2020

Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerization

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12 December 2020

The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein

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12 December 2020

Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models

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12 December 2020

Steroid receptor interactions with heat shock protein and immunophilin chaperones

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12 December 2020

Calcineurin is required for virulence of Cryptococcus neoformans

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12 December 2020

Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen

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12 December 2020

A versatile synthetic dimerizer for the regulation of protein-protein interactions

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12 December 2020

Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface

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12 December 2020

Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment

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12 December 2020

FK506 and the role of immunophilins in nerve regeneration

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12 December 2020

Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

1 reference

12 December 2020

Chicken FK506-binding protein, FKBP65, a member of the FKBP family of peptidylprolyl cis-trans isomerases, is only partially inhibited by FK506.

1 reference

12 December 2020

Neural actions of immunophilin ligands.

1 reference

12 December 2020

The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1

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12 December 2020

Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90

1 reference

12 December 2020

TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins

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12 December 2020

Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity

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12 December 2020

A novel immunophilin ligand: distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease.

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12 December 2020

Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins

1 reference

12 December 2020

Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer.

1 reference

12 December 2020

Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51.

1 reference

12 December 2020

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

1 reference

12 December 2020

Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo

1 reference

12 December 2020

Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution

1 reference

12 December 2020

Three amino acid residues determine selective binding of FK506-binding protein 12.6 to the cardiac ryanodine receptor

1 reference

12 December 2020

Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties.

1 reference

12 December 2020

Systemic treatment with GPI 1046 improves spatial memory and reverses cholinergic neuron atrophy in the medial septal nucleus of aged mice

1 reference

12 December 2020

Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin

1 reference

12 December 2020

Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum

1 reference

12 December 2020

The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle

1 reference

12 December 2020

Investigating protein-ligand interactions with a mutant FKBP possessing a designed specificity pocket

1 reference

12 December 2020

A ligand-reversible dimerization system for controlling protein-protein interactions

1 reference

12 December 2020

The small molecule FKBP ligand GPI 1046 induces partial striatal re-innervation after intranigral 6-hydroxydopamine lesion in rats

1 reference

12 December 2020

Rapamycin in transplantation: a review of the evidence

1 reference

12 December 2020

Failure of GPI compounds to display neurotrophic activity in vitro and in vivo

1 reference

12 December 2020

Immunophilin ligands can prevent progressive dopaminergic degeneration in animal models of Parkinson's disease.

1 reference

12 December 2020

Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons

1 reference

12 December 2020

Intravenous safety and pharmacokinetics of a novel dimerizer drug, AP1903, in healthy volunteers

1 reference

12 December 2020

Crystal structure of Mip, a prolylisomerase from Legionella pneumophila

1 reference

12 December 2020

The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1.

1 reference

12 December 2020

Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors

1 reference

12 December 2020

Ryanodine receptors, FKBP12, and heart failure

1 reference

12 December 2020

Dimerizer-induced proliferation of genetically modified hepatocytes

1 reference

12 December 2020

Regulation of endogenous gene expression with a small-molecule dimerizer

1 reference

12 December 2020

A bacterial small-molecule three-hybrid system

1 reference

12 December 2020

Neuroprotective and antioxidant properties of FKBP-binding immunophilin ligands are independent on the FKBP12 pathway in human cells

1 reference

12 December 2020

Neuroimmunophilin ligand V-10,367 is neuroprotective after 24-hour delayed administration in a mouse model of diffuse traumatic brain injury

1 reference

12 December 2020

The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys

1 reference

12 December 2020

The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo

1 reference

12 December 2020

The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response

1 reference

12 December 2020

Differential effects of immunophilin-ligands (FK506 and V-10,367) on survival and regeneration of rat retinal ganglion cells in vitro and after optic nerve crush in vivo

1 reference

12 December 2020

Conditional protein splicing: a new tool to control protein structure and function in vitro and in vivo.

1 reference

12 December 2020

Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands

1 reference

12 December 2020

Conditional protein alleles using knockin mice and a chemical inducer of dimerization

1 reference

12 December 2020

Regulating cell surface glycosylation by small molecule control of enzyme localization

1 reference

12 December 2020

1 reference

12 December 2020

Chemical dimerizers and three-hybrid systems: scanning the proteome for targets of organic small molecules

1 reference

12 December 2020

Design, synthesis and structure of non-macrocyclic inhibitors of FKBP12, the major binding protein for the immunosuppressant FK506.

1 reference

12 December 2020

Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain

1 reference

12 December 2020

Pharmacological regulation of the insulin receptor signaling pathway mimics insulin action in cells transduced with viral vectors.

1 reference

12 December 2020

Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506.

1 reference

12 December 2020

Non-FK506-binding protein-12 neuroimmunophilin ligands increase neurite elongation and accelerate nerve regeneration.

1 reference

12 December 2020

Characterization of the FKBP.rapamycin.FRB ternary complex

1 reference

12 December 2020

Physiological role for the cochaperone FKBP52 in androgen receptor signaling

1 reference

12 December 2020

An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways

1 reference

12 December 2020

Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels

1 reference

12 December 2020

Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands

1 reference

12 December 2020

SUMO modification through rapamycin-mediated heterodimerization reveals a dual role for Ubc9 in targeting RanGAP1 to nuclear pore complexes

1 reference

12 December 2020

Glucocorticoid resistance in squirrel monkeys results from a combination of a transcriptionally incompetent glucocorticoid receptor and overexpression of the glucocorticoid receptor co-chaperone FKBP51.

1 reference

12 December 2020

The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV-1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium load

1 reference

12 December 2020

Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus

1 reference

12 December 2020

A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules

1 reference

12 December 2020

A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease

1 reference

12 December 2020

Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections

1 reference

12 December 2020

Solution structure of the Legionella pneumophila Mip-rapamycin complex

1 reference

12 December 2020

Novel strategies to combat bacterial virulence

1 reference

12 December 2020

FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53

1 reference

12 December 2020

Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation

1 reference

12 December 2020

Fluorescent probes to characterise FK506-binding proteins

1 reference

12 December 2020

Antivirulence drugs to target bacterial secretion systems

1 reference

12 December 2020

Organelle-specific, rapid induction of molecular activities and membrane tethering

1 reference

12 December 2020

Rapid inactivation of proteins by rapamycin-induced rerouting to mitochondria

1 reference

12 December 2020

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks

1 reference

12 December 2020

Engineered allosteric activation of kinases in living cells

1 reference

12 December 2020

Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes.

1 reference

12 December 2020

Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors

1 reference

12 December 2020

Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay

1 reference

12 December 2020

Conditionally controlling nuclear trafficking in yeast by chemical-induced protein dimerization

1 reference

12 December 2020

Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein

1 reference

12 December 2020

A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity

1 reference

12 December 2020

Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP.

1 reference

12 December 2020

Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules

1 reference

12 December 2020

Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52).

1 reference

12 December 2020

Organization and function of the FKBP52 and FKBP51 genes

1 reference

12 December 2020

The structure of a Burkholderia pseudomallei immunophilin–inhibitor complex reveals new approaches to antimicrobial development

1 reference

12 December 2020

Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90

1 reference

12 December 2020

Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

1 reference

12 December 2020

Targeting FKBP isoforms with small-molecule ligands

1 reference

12 December 2020

The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress.

1 reference

12 December 2020

FKBP51 and FKBP52 in signaling and disease

1 reference

12 December 2020

FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior.

1 reference

12 December 2020

A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.

1 reference

12 December 2020

The chemical biology of immunophilin ligands

1 reference

12 December 2020

Targeting colorectal cancer stem cells with inducible caspase-9

1 reference

12 December 2020

A caspase 8-based suicide switch induces apoptosis in nanobody-directed chimeric receptor expressing T cells

1 reference

12 December 2020

Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52

1 reference

12 December 2020

Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52

1 reference

12 December 2020

The role of FK506-binding proteins 12 and 12.6 in regulating cardiac function

1 reference

12 December 2020

Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells

1 reference

12 December 2020

The prospect of FKBP51 as a drug target

1 reference

12 December 2020

Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes

1 reference

12 December 2020

The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.

1 reference

12 December 2020

Differential trafficking of transport vesicles contributes to the localization of dendritic proteins

1 reference

12 December 2020

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

1 reference

12 December 2020

Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression

1 reference

12 December 2020

Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions

1 reference

12 December 2020

The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity

1 reference

12 December 2020

The precise chemical-physical nature of the pharmacore in FK506 binding protein inhibition: ElteX, a New class of nanomolar FKBP12 ligands.

1 reference

12 December 2020

Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin

1 reference

12 December 2020

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

1 reference

12 December 2020

InterAKTions with FKBPs--mutational and pharmacological exploration

1 reference

12 December 2020

Rational design of a ligand-controlled protein conformational switch

1 reference

12 December 2020

Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control

1 reference

12 December 2020

Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.

1 reference

12 December 2020

Crystal structures of the free and ligand-bound FK1-FK2 domain segment of FKBP52 reveal a flexible inter-domain hinge

1 reference

12 December 2020

Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism

1 reference

12 December 2020

Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice

1 reference

12 December 2020

(1)H, (13)C and (15)N resonance assignments of human FK506 binding protein 25

1 reference

12 December 2020

Photocleavable dimerizer for the rapid reversal of molecular trap antagonists

1 reference

12 December 2020

Ligand-gated split-kinases.

1 reference

12 December 2020

FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation

1 reference

12 December 2020

Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1

1 reference

12 December 2020

Depletion of FKBP51 in female mice shapes HPA axis activity

1 reference

12 December 2020

A rapidly reversible chemical dimerizer system to study lipid signaling in living cells.

1 reference

12 December 2020

FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance

1 reference

12 December 2020

Microbial peptidyl-prolyl cis/trans isomerases (PPIases): virulence factors and potential alternative drug targets

1 reference

12 December 2020

Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.

1 reference

12 December 2020

Stereoselective construction of the 5-hydroxy diazabicyclo[4.3.1]decane-2-one scaffold, a privileged motif for FK506-binding proteins

1 reference

12 December 2020

Small molecule gated split-tyrosine phosphatases and orthogonal split-tyrosine kinases.

1 reference

12 December 2020

Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)

1 reference

12 December 2020

Selective inhibitors of the FK506-binding protein 51 by induced fit

1 reference

12 December 2020

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

1 reference

12 December 2020

FKBPs and their role in neuronal signaling

1 reference

12 December 2020

A split-Cas9 architecture for inducible genome editing and transcription modulation

1 reference

12 December 2020

Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma

1 reference

12 December 2020

Reversible chemical dimerizer-induced recovery of PIP2 levels moves clathrin to the plasma membrane

1 reference

12 December 2020

Novel Cycloheximide Derivatives Targeting the Moonlighting Protein Mip Exhibit Specific Antimicrobial Activity Against Legionella pneumophila

1 reference

12 December 2020

Therapeutic Targeting of the FKBP52 Co-Chaperone in Steroid Hormone Receptor-Regulated Physiology and Disease.

1 reference

12 December 2020

Recent Progress in FKBP Ligand Development

1 reference

12 December 2020

Conformational Dynamics in FKBP Domains: Relevance to Molecular Signaling and Drug Design

1 reference

12 December 2020

Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties.

1 reference

12 December 2020

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

1 reference

12 December 2020

FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma.

1 reference

12 December 2020

The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling.

1 reference

12 December 2020

Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications

1 reference

12 December 2020

Structure-Affinity Relationship Analysis of Selective FKBP51 Ligands

1 reference

12 December 2020

Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation

1 reference

12 December 2020

Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506.

1 reference

12 December 2020

Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin

1 reference

12 December 2020

Rapamycin-induced oligomer formation system of FRB-FKBP fusion proteins

1 reference

12 December 2020

The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling

1 reference

12 December 2020

Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51

1 reference

12 December 2020

Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function

1 reference

12 December 2020

Aryl Hydrocarbon Receptor-interacting Protein-like 1 Is an Obligate Chaperone of Phosphodiesterase 6 and Is Assisted by the γ-Subunit of Its Client

1 reference

12 December 2020

Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2

1 reference

12 December 2020

Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds

1 reference

12 December 2020

FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone.

1 reference

12 December 2020

Improving the safety of T-Cell therapies using an inducible caspase-9 gene

1 reference

12 December 2020

TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends.

1 reference

12 December 2020

Inhibitors of macrophage infectivity potentiator-like PPIases affect neisserial and chlamydial pathogenicity

1 reference

12 December 2020

Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei

1 reference

12 December 2020

Structural Basis for Gating and Activation of RyR1.

1 reference

12 December 2020

An improved reversibly dimerizing mutant of the FK506-binding protein FKBP

1 reference

12 December 2020

Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes.

1 reference

12 December 2020

Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52.

1 reference

12 December 2020

Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling.

1 reference

12 December 2020

The Function of FK506-Binding Protein 13 in Protein Quality Control Protects Plasma Cells from Endoplasmic Reticulum Stress-Associated Apoptosis

1 reference

12 December 2020

FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch

1 reference

12 December 2020

Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.

1 reference

12 December 2020

A calcineurin antifungal strategy with analogs of FK506.

1 reference

12 December 2020

Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.

1 reference

12 December 2020

Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation.

1 reference

12 December 2020

FKBP3 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through Regulating Sp1/HDAC2/p27.

1 reference

12 December 2020

Rapid and reversible epigenome editing by endogenous chromatin regulators

1 reference

12 December 2020

AIPL1: A specialized chaperone for the phototransduction effector.

1 reference

12 December 2020

The integrity and organization of the human AIPL1 functional domains is critical for its role as a HSP90-dependent co-chaperone for rod PDE6.

1 reference

12 December 2020

A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma.

1 reference

12 December 2020

Molecular dynamics simulation, binding free energy calculation and unbinding pathway analysis on selectivity difference between FKBP51 and FKBP52: Insight into the molecular mechanism of isoform selectivity.

1 reference

12 December 2020

The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module

1 reference

12 December 2020

Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity.

1 reference

12 December 2020

Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.

1 reference

12 December 2020

Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

1 reference

12 December 2020

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function.

1 reference

12 December 2020

Controlled dimerization of insulin-like growth factor-1 and insulin receptors reveal shared and distinct activities of holo and hybrid receptors

1 reference

12 December 2020

The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability.

1 reference

12 December 2020

Bacterial gene control by DNA looping using engineered dimeric transcription activator like effector (TALE) proteins.

1 reference

12 December 2020

Long-Term Sirolimus for Primary Immunosuppression in Heart Transplant Recipients

1 reference

12 December 2020

The stress regulator FKBP51: a novel and promising druggable target for the treatment of persistent pain states across sexes.

1 reference

12 December 2020

Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders.

1 reference

12 December 2020

Sirolimus in Liver Transplant Recipients with Hepatocellular Carcinoma: An Updated Meta-Analysis

1 reference

12 December 2020

Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins.

1 reference

12 December 2020

The dTAG system for immediate and target-specific protein degradation.

1 reference

12 December 2020

Chemically induced proximity in biology and medicine.

1 reference

12 December 2020

A Rapamycin-Activated Caspase 9-Based Suicide Gene.

1 reference

12 December 2020

FKBP12.6 protects heart from AngII-induced hypertrophy through inhibiting Ca2+ /calmodulin-mediated signalling pathways in vivo and in vitro.

1 reference

12 December 2020

An Inexpensive and Scalable Synthesis of Shld

1 reference

12 December 2020

Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD

1 reference

12 December 2020

Elucidation of the FKBP25-60S Ribosomal Protein L7a Stress Response Signaling During Ischemic Injury

1 reference

12 December 2020

FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes

1 reference

12 December 2020

FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti-inflammatory drug target

1 reference

12 December 2020