Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions (Q61456169)

12 December 2020

Novel proteinaceous infectious particles cause scrapie

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12 December 2020

Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein

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12 December 2020

Molecular biology and pathogenesis of prion diseases

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12 December 2020

pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231)

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12 December 2020

The cellular prion protein binds copper in vivo

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12 December 2020

The cellular prion protein binds copper in vivo

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12 December 2020

A transmembrane form of the prion protein in neurodegenerative disease

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12 December 2020

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12 December 2020

Familial mutations and the thermodynamic stability of the recombinant human prion protein

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12 December 2020

Copper stimulates endocytosis of the prion protein

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12 December 2020

Influence of amino acid substitutions related to inherited human prion diseases on the thermodynamic stability of the cellular prion protein

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12 December 2020

Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.

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12 December 2020

Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein

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12 December 2020

NMR solution structure of the human prion protein

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12 December 2020

The Chaperone Protein BiP Binds to a Mutant Prion Protein and Mediates Its Degradation by the Proteasome

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12 December 2020

Cleavage of the amino terminus of the prion protein by reactive oxygen species.

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12 December 2020

Identification of the Cu2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy

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12 December 2020

Folding of prion protein to its native alpha-helical conformation is under kinetic control

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12 December 2020

Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region

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12 December 2020

Location and properties of metal-binding sites on the human prion protein.

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12 December 2020

Internalization of mammalian fluorescent cellular prion protein and N-terminal deletion mutants in living cells

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12 December 2020

Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein

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12 December 2020

Molecular features of the copper binding sites in the octarepeat domain of the prion protein

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12 December 2020

Metal ions and prion diseases

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12 December 2020

Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection

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12 December 2020

Exploring the propensities of helices in PrP(C) to form beta sheet using NMR structures and sequence alignments

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12 December 2020

Mutations of the prion protein gene phenotypic spectrum

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12 December 2020

Glycosylation and prion protein.

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12 December 2020

Copper coordination in the full-length, recombinant prion protein

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12 December 2020

Influence of pH on NMR structure and stability of the human prion protein globular domain

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12 December 2020

Conformational polymorphism of the amyloidogenic peptide homologous to residues 113-127 of the prion protein

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12 December 2020

The Octapeptide Repeats in Mammalian Prion Protein Constitute a pH-dependent Folding and Aggregation Site

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12 December 2020

Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro

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12 December 2020

The effect of disease-associated mutations on the folding pathway of human prion protein

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12 December 2020

Copper binding in the prion protein

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12 December 2020

Evidence for assembly of prions with left-handed beta-helices into trimers

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12 December 2020

Probing the instabilities in the dynamics of helical fragments from mouse PrPC.

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12 December 2020

Comparative computational analysis of prion proteins reveals two fragments with unusual structural properties and a pattern of increase in hydrophobicity associated with disease-promoting mutations

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12 December 2020

The highways and byways of prion protein trafficking

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12 December 2020

Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR: the unstructured N terminus facilitates the coordination of six copper2+ ions at physiological concentrations

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12 December 2020

Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress

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12 December 2020

The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4.

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12 December 2020

A spectroscopic and voltammetric study of the pH-dependent Cu(II) coordination to the peptide GGGTH: relevance to the fifth Cu(II) site in the prion protein

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12 December 2020

Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases

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12 December 2020

Multiple forms of copper (II) co-ordination occur throughout the disordered N-terminal region of the prion protein at pH 7.4.

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12 December 2020

The intriguing prion disorders

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12 December 2020

The possible role of protein X, a putative auxiliary factor in pathological prion replication, in regulating a physiological endoproteolytic cleavage of cellular prion protein.

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12 December 2020

The affinity of copper binding to the prion protein octarepeat domain: evidence for negative cooperativity

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12 December 2020

Copper and the prion protein: methods, structures, function, and disease

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12 December 2020

Structural and Dynamic Characterization of Copper(II) Binding of the Human Prion Protein Outside the Octarepeat Region

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12 December 2020

Structural properties of prion protein protofibrils and fibrils: an experimental assessment of atomic models

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12 December 2020

Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.

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12 December 2020

Specific features of the prion protein transmembrane domain regulate nascent chain orientation.

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12 December 2020

Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins

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12 December 2020

Clustered negative charges on the lipid membrane surface induce beta-sheet formation of prion protein fragment 106-126.

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12 December 2020

Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure

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12 December 2020

Deconvoluting the Cu2+ binding modes of full-length prion protein

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12 December 2020

Mechanisms of prion protein assembly into amyloid

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12 December 2020

LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein

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12 December 2020

Physiology of the prion protein

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12 December 2020

Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils

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12 December 2020

Folding of the prion peptide GGGTHSQW around the copper(II) ion: identifying the oxygen donor ligand at neutral pH and probing the proximity of the tryptophan residue to the copper ion.

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12 December 2020

The concept of translocational regulation

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12 December 2020

Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model.

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12 December 2020

Crystal structure of human prion protein bound to a therapeutic antibody

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12 December 2020

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

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12 December 2020

Hydrogen/deuterium exchange mass spectrometry identifies two highly protected regions in recombinant full-length prion protein amyloid fibrils

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12 December 2020

Interaction of copper(II) with the prion peptide fragment HuPrP(76-114) encompassing four histidyl residues within and outside the octarepeat domain.

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12 December 2020

Prion protein biosynthesis and its emerging role in neurodegeneration

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12 December 2020

Copper binding extrinsic to the octarepeat region in the prion protein

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12 December 2020

Prion protein-detergent micelle interactions studied by NMR in solution

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12 December 2020

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12 December 2020

The consequences of pathogenic mutations to the human prion protein

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12 December 2020

Evaluation of copper2+ affinities for the prion protein

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12 December 2020

Prions: protein aggregation and infectious diseases

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12 December 2020

Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations

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12 December 2020

Protein aggregation diseases: pathogenicity and therapeutic perspectives

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12 December 2020

Prion Fibrillization Is Mediated by a Native Structural Element That Comprises Helices H2 and H3

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12 December 2020

Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

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12 December 2020

NMR Structure of the Human Prion Protein with the Pathological Q212P Mutation Reveals Unique Structural Features

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12 December 2020

Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding

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12 December 2020

Experimental approaches to the interaction of the prion protein with nucleic acids and glycosaminoglycans: Modulators of the pathogenic conversion

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12 December 2020

Spectroscopic and electronic structure studies of copper(II) binding to His111 in the human prion protein fragment 106-115: evaluating the role of protons and methionine residues

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12 December 2020

Discordant and chameleon sequences: their distribution and implications for amyloidogenicity

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12 December 2020

Copper(II)-induced secondary structure changes and reduced folding stability of the prion protein

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12 December 2020

Prion protein and its conformational conversion: a structural perspective

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12 December 2020

Common Structural Traits across Pathogenic Mutants of the Human Prion Protein and Their Implications for Familial Prion Diseases

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12 December 2020

Copper redox cycling in the prion protein depends critically on binding mode

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12 December 2020

Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions

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12 December 2020

Fatal prion disease in a mouse model of genetic E200K Creutzfeldt-Jakob disease

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12 December 2020

The prion protein unstructured N-terminal region is a broad-spectrum molecular sensor with diverse and contrasting potential functions

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12 December 2020

Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

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12 December 2020

Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders.

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12 December 2020

High-resolution structure of infectious prion protein: the final frontier

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12 December 2020

Effects of the pathological Q212P mutation on human prion protein non-octarepeat copper-binding site

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12 December 2020

The Rich Electrochemistry and Redox Reactions of the Copper Sites in the Cellular Prion Protein

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12 December 2020

Structural models for Cu(II) bound to the fragment 92-96 of the human prion protein

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12 December 2020

Zinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interface

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12 December 2020

Proteolytic processing of the prion protein in health and disease.

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12 December 2020

Flotillin-1 mediates PrPc endocytosis in the cultured cells during Cu²⁺ stimulation through molecular interaction

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12 December 2020

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.

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12 December 2020

Computational studies on the prion protein

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12 December 2020

A new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein

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12 December 2020

PrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease?

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12 December 2020

Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity

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12 December 2020

Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation.

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12 December 2020

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion.

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12 December 2020

Role of Prion Disease-Linked Mutations in the Intrinsically Disordered N-Terminal Domain of the Prion Protein

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12 December 2020

Spectroscopic and Theoretical Study of Cu(I) Binding to His111 in the Human Prion Protein Fragment 106-115.

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12 December 2020

Interaction between Prion Protein's Copper-Bound Octarepeat Domain and a Charged C-Terminal Pocket Suggests a Mechanism for N-Terminal Regulation

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12 December 2020

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

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12 December 2020

Structural Modeling of Human Prion Protein's Point Mutations

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12 December 2020

Copper- and Zinc-Promoted Interdomain Structure in the Prion Protein: A Mechanism for Autoinhibition of the Neurotoxic N-Terminus

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12 December 2020

Neuroprotective alpha-cleavage of the human prion protein significantly impacts Cu(ii) coordination at its His111 site

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12 December 2020

Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions

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12 December 2020