RB regulates the stability and the apoptotic function of p53 via MDM2 (Q74607074)

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12 November 2019

title

RB regulates the stability and the apoptotic function of p53 via MDM2 (English)

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12 November 2019

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J K Hsieh

1

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12 November 2019

F S Chan

2

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12 November 2019

D J O'Connor

3

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12 November 2019

S Mittnacht

4

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12 November 2019

S Zhong

5

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12 November 2019

X Lu

6

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12 November 2019

publication date

1 February 1999

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12 November 2019

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12 November 2019

volume

3

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12 November 2019

issue

2

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12 November 2019

page(s)

181-193

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Deletion of RB exons 24 and 25 causes low-penetrance retinoblastoma

12 November 2019

cites work

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7 January 2021

pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.

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The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif

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Transcriptional activation by p53 correlates with suppression of growth but not transformation.

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High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers

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The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

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E2F-1-induced p53-independent apoptosis in transgenic mice.

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7 January 2021

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

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7 January 2021

Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner.

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7 January 2021

Regulation of the specific DNA binding function of p53

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7 January 2021

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

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p53: puzzle and paradigm

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7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

p53, the cellular gatekeeper for growth and division

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7 January 2021

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

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7 January 2021

Control of pRB phosphorylation

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7 January 2021

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

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7 January 2021

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

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7 January 2021

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors

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7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

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7 January 2021

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

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7 January 2021

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7 January 2021

Repression of p53-mediated transcription by MDM2: a dual mechanism

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7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

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7 January 2021

The retinoblastoma protein and cell cycle control

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7 January 2021

Mechanism of active transcriptional repression by the retinoblastoma protein

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7 January 2021

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

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7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

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7 January 2021

Interaction between the retinoblastoma protein and the oncoprotein MDM2

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7 January 2021

Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma

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7 January 2021

10.1016/S1097-2765(00)80309-3

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10078201%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

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