Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins (Q78397249)

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scientific article published on 01 October 2002

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English	Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins	scientific article published on 01 October 2002

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388585%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins (English)

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14 December 2019

amyotrophic lateral sclerosis

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author name string

Krishna Puttaparthi

1

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14 December 2019

William L Gitomer

2

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14 December 2019

Uma Krishnan

3

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14 December 2019

Marjatta Son

4

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14 December 2019

Bhagya Rajendran

5

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14 December 2019

Jeffrey L Elliott

6

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14 December 2019

publication date

1 October 2002

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14 December 2019

Journal of Neuroscience

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14 December 2019

22

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14 December 2019

20

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14 December 2019

8790-8796

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14 December 2019

Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metallothionein expression is altered in a transgenic murine model of familial amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zinc metallothionein imported into liver mitochondria modulates respiration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Copper converts the cellular prion protein into a protease-resistant species that is distinct from the scrapie isoform

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zn(2+) inhibits the anion conductance of the glutamate transporter EEAT4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current status of SOD1 mutations in familial amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zinc and copper in the pathogenesis of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a novel role of copper-zinc superoxide dismutase in zinc metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of metallothionein in the brain of rat and mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MT-III, a brain-specific member of the metallothionein gene family

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfer of copper and zinc from ionic and metallothionein-bound forms to Cu, Zn--superoxide dismutase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BAX is required for neuronal death after trophic factor deprivation and during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of different metallothionein messenger ribonucleic acids in motor cortex, spinal cord and liver from patients with amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superox

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide dismutase catalyzes nitration of tyrosines by peroxynitrite in the rod and head domains of neurofilament-L.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of zinc transfer between thionein, metallothionein, and zinc proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate uptake is decreased tardively in the spinal cord of FALS mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The elusive function of metallothioneins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12388585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-20-08790.2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388585%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388585%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12388585%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

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