Lesch-Nyhan syndrome and its pathogenesis: normal nicotinamide-adenine dinucleotide but reduced ATP concentrations that correlate with reduced poly(ADP-ribose) synthetase activity in HPRT-deficient lymphoblasts (Q71376808)

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scientific article published on 01 January 1995

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English	Lesch-Nyhan syndrome and its pathogenesis: normal nicotinamide-adenine dinucleotide but reduced ATP concentrations that correlate with reduced poly(ADP-ribose) synthetase activity in HPRT-deficient lymphoblasts	scientific article published on 01 January 1995

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scholarly article

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18 October 2019

Lesch-Nyhan syndrome and its pathogenesis: normal nicotinamide-adenine dinucleotide but reduced ATP concentrations that correlate with reduced poly(ADP-ribose) synthetase activity in HPRT-deficient lymphoblasts (English)

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18 October 2019

author name string

G M McCreanor

1

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18 October 2019

R A Harkness

2

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18 October 2019

publication date

1 January 1995

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18 October 2019

Journal of Inherited Metabolic Disease

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18 October 2019

18

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18 October 2019

6

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18 October 2019

737-747

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18 October 2019

Defining apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

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Polyamines: cellular regulators? Introductory remarks

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

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Apoptosis, oncosis, and necrosis. An overview of cell death

1 reference

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12 December 2020

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Effect of a failure of energy supply on adenine nucleotide breakdown in placentae and other fetal tissues from rat and guinea pig.

1 reference

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12 December 2020

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Poly(ADP-ribose) polymerase inhibitors preserve oxidized nicotinamide adenine dinucleotide and adenosine 5'-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis

1 reference

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12 December 2020

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DNA strand breaks, NAD metabolism, and programmed cell death

1 reference

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12 December 2020

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Human longevity and aging: possible role of reactive oxygen species

1 reference

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Lesch-Nyhan syndrome and its pathogenesis: purine concentrations in plasma and urine with metabolite profiles in CSF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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Measurement of free nucleotides in cultured human lymphoid cells using high pressure liquid chromatography

1 reference

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12 December 2020

based on heuristic

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Observations on the growth in vitro of myeloid progenitor cells and fibroblasts from hemizygotes and heterozygotes for "complete" and "partial" hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency, and their relevance to the pathogenesi

1 reference

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12 December 2020

based on heuristic

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Decreased amino acids in various brain areas of patients with Lesch-Nyhan syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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ADP-ribosylation of proteins: a ubiquitous cellular control mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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NAD(+)-dependent repair of damaged DNA by human cell extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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Hypoxanthine phosphoribosyl transferase deficiency, haematopoiesis and fertility in the mouse

1 reference

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12 December 2020

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The Fritz-Lipmann lecture. DNA repair in human cells. Biochemistry of the hereditary diseases Fanconi's anaemia and Cockayne syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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Protein metabolism in phenylketonuria and Lesch-Nyhan syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid changes in initiation-limited rates of protein synthesis in rat thymic lymphocytes correlate with energy charge

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular protein degradation in mammalian and bacterial cells: Part 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Turnover of purine nucleotides in rabbit erythrocytes I. Studies in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and comparison of poly(adenosine diphosphoribose) synthesis and DNA synthesis in nucleotide-permeable cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle activity and motor neuron death in the spinal cord of the chick embryo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cerebral protein synthesis by epileptic seizures without motor manifestations

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gel-electrophoretic analysis of protein ADP-ribosylation in polyoma virus-transformed and non-transformed BHK-21/C13 fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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Glutamyl ribose 5-phosphate storage disease. A hereditary defect in the degradation of poly(ADP-ribosylated) proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human phosphoribosylpyrophosphate synthetase. Kinetic mechanism and end product inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poly(adenosinediphosphoribose) polymerase inhibitors stimulate unscheduled DNA synthesis in normal human lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced purine nucleotide content and poly(ADP-ribose) synthetase activity in HPRT-deficient human lymphoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of respiration and ATP synthesis in mammalian mitochondria and cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of poly(ADP-ribose) formation in DNA repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probable mechanisms of regulation of the utilization of dietary tryptophan, nicotinamide and nicotinic acid as precursors of nicotinamide nucleotides in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purine nucleotide cycles and their metabolic role

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of neonatal status epilepticus on rat brain development

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eukaryotic nuclear ADP-ribosylation reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolism of high intakes of tryptophan, nicotinamide and nicotinic acid in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate, calcium, and free radicals as mediators of ischemic brain damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Instability and decay of the primary structure of DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permanent lymphoid lines from genetically marked lymphocytes: success with lymphocytes recovered from frozen storage

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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Clinical, post-mortem, biochemical and therapeutic observations on the Lesch-Nyhan syndrome with particular reference to the Neurological manifestations

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of catabolism in controlling tissue concentrations of nicotinamide nucleotide coenzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADP-ribosylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for active purine nucleoside cycles in human mononuclear cells and cultured fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of DNA ligase activity by poly(ADP-ribose)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lesch-Nyhan syndrome: growth delay, testicular atrophy and a partial failure of the 11 beta-hydroxylation of steroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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Normal intelligence in the Lesch-Nyhan syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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Thyroid thermogenesis and active sodium transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750613

12 December 2020

based on heuristic

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Identifiers

10.1007/BF02436765

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8750613%20AND%20SRC:MED&resulttype=core&format=json

18 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8750613%20AND%20SRC:MED&resulttype=core&format=json

18 October 2019

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