Synthesis and evaluation of geldanamycin-testosterone hybrids (Q73923190)

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7 November 2019

title

Synthesis and evaluation of geldanamycin-testosterone hybrids (English)

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7 November 2019

4

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7 November 2019

Ouathek Ouerfelli

5

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7 November 2019

author name string

S D Kuduk

1

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7 November 2019

T C Harris

2

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7 November 2019

F F Zheng

3

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7 November 2019

N Rosen

6

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7 November 2019

S J Danishefsky

7

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7 November 2019

language of work or name

English

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publication date

1 June 2000

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Bioorganic & Medicinal Chemistry Letters

7 November 2019

published in

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7 November 2019

volume

10

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7 November 2019

issue

11

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7 November 2019

page(s)

1303-1306

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Binding of benzoquinoid ansamycins to p100 correlates with their ability to deplete the erbB2 gene product p185

7 November 2019

cites work

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Herbimycin A induces the 20 S proteasome- and ubiquitin-dependent degradation of receptor tyrosine kinases

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

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7 January 2021

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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7 January 2021

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

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7 January 2021

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

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7 January 2021

The Hsp90 complex--a super-chaperone machine as a novel drug target

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7 January 2021

Signal-transduction cascades as targets for therapeutic intervention by natural products

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7 January 2021

The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors

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7 January 2021

Hsp90 Regulates Androgen Receptor Hormone Binding Affinityin Vivo

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7 January 2021

The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase

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7 January 2021

Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

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7 January 2021

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

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7 January 2021

Geldanamycin prevents nuclear translocation of mutant p53.

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7 January 2021

Synthesis and evaluation of geldanamycin-estradiol hybrids

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7 January 2021

Synthesis of high affinity fluorine-substituted ligands for the androgen receptor. Potential agents for imaging prostatic cancer by positron emission tomography

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7 January 2021

Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives

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7 January 2021

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships

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7 January 2021

10.1016/S0960-894X(00)00208-0

Identifiers

DOI

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7 November 2019

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