Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation (Q84523946)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21739598%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21739598%20AND%20SRC:MED&resulttype=core&format=json

randomized controlled trial

7 February 2020

main subject

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Ira T Lott

1

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7 February 2020

Eric Doran

2

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7 February 2020

Vinh Q Nguyen

3

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7 February 2020

Anne Tournay

4

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7 February 2020

Elizabeth Head

5

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7 February 2020

Daniel L Gillen

6

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7 February 2020

publication date

7 July 2011

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American Journal of Medical Genetics

7 February 2020

published in

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7 February 2020

volume

155A

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7 February 2020

issue

8

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7 February 2020

page(s)

1939-1948

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Assessment of activities of daily living in dementia: development of the Bristol Activities of Daily Living Scale.

7 February 2020

cites work

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12 December 2020

Oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans

1 reference

12 December 2020

Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines

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12 December 2020

The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches.

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12 December 2020

Down's syndrome: a pathology involving the lack of balance of reactive oxygen species

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12 December 2020

Dementia and mortality in persons with Down's syndrome

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12 December 2020

Simultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase

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12 December 2020

Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease

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12 December 2020

Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E.

1 reference

12 December 2020

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

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12 December 2020

Severe impairment battery. A neuropsychological test for severely demented patients.

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12 December 2020

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

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12 December 2020

Molecular basis of pharmacotherapies for cognition in Down syndrome

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12 December 2020

Predictive factors of discontinuation and switch of cholinesterase inhibitors in community-dwelling patients with Alzheimer's disease: a 2-year prospective, multicentre, cohort study

1 reference

12 December 2020

Vitamin E and cognitive decline in older persons

1 reference

12 December 2020

ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons.

1 reference

12 December 2020

Vitamin E increases S100B-mediated microglial activation in an S100B-overexpressing mouse model of pathological aging

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12 December 2020

Dietary intake of antioxidants and risk of Alzheimer disease

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12 December 2020

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study

1 reference

12 December 2020

Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.

1 reference

12 December 2020

Effect of Coenzyme Q10 in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial

1 reference

12 December 2020

Action of ascorbic acid as a scavenger of active and stable oxygen radicals

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12 December 2020

Alzheimer's disease in Down syndrome: neurobiology and risk.

1 reference

12 December 2020

Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation.

1 reference

12 December 2020

Vitamins in human arteriosclerosis with emphasis on vitamin C and vitamin E.

1 reference

12 December 2020

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease

1 reference

12 December 2020

Requirement for, Promotion, or Inhibition by α-Tocopherol of Radical-Induced Initiation of Plasma Lipoprotein Lipid Peroxidation

1 reference

12 December 2020

Vitamin E paradox in Alzheimer's disease: it does not prevent loss of cognition and may even be detrimental.

1 reference

12 December 2020

Antioxidant approaches for the treatment of Alzheimer's disease

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12 December 2020

Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage

1 reference

12 December 2020

Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant

1 reference

12 December 2020

Oxidative alterations in Alzheimer's disease

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12 December 2020

Effect of leucovorin (folinic acid) on the developmental quotient of children with Down's syndrome (trisomy 21) and influence of thyroid status

1 reference

12 December 2020

Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome

1 reference

12 December 2020

Mitochondrial dysfunction in mouse trisomy 16 brain

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12 December 2020

Oxidative stress and cognitive ability in adults with Down syndrome.

1 reference

12 December 2020

Antioxidant vitamin intake and risk of Alzheimer disease

1 reference

12 December 2020

Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

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12 December 2020

Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome

1 reference

12 December 2020

Vitamin E for Alzheimer's disease and mild cognitive impairment

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12 December 2020

Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines

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12 December 2020

Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.

1 reference

12 December 2020

A randomized trial of vitamin E supplementation and cognitive function in women

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12 December 2020

NIA-funded Alzheimer centers are more efficient than commercial clinical recruitment sites for conducting secondary prevention trials of dementia

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12 December 2020

Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis.

1 reference

12 December 2020

Evaluation of a screening instrument for dementia in ageing mentally retarded persons

1 reference

12 December 2020

Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial

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12 December 2020

Early glycoxidation damage in brains from Down's syndrome.

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12 December 2020

Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia

1 reference

12 December 2020

Dementia in people with Down's syndrome.

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12 December 2020

Supplementation of Diets with α-Tocopherol Reduces Serum Concentrations of γ- and δ-Tocopherol in Humans

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12 December 2020

Complementary and alternative medicine in developmental disabilities

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12 December 2020

The exercise redox paradigm in the Down's syndrome: improvements in motor function and increases in blood oxidative status in young adults.

1 reference

12 December 2020

Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study.

1 reference

12 December 2020

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

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12 December 2020

Neuroanatomy of Down's syndrome: a high-resolution MRI study.

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12 December 2020

Prevalence of dementia in intellectual disability using different diagnostic criteria.

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12 December 2020

Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome.

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12 December 2020

Folate, vitamin E, and acetyl-L-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid-beta

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12 December 2020

Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses

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12 December 2020

Human Atherosclerotic Plaque Contains Both Oxidized Lipids and Relatively Large Amounts of α-Tocopherol and Ascorbate

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12 December 2020

A case for cautious optimism

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12 December 2020

Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia

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12 December 2020

Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome

1 reference

12 December 2020

Vitamin E and donepezil for the treatment of mild cognitive impairment

1 reference

12 December 2020

Further evaluation of the Dementia Questionnaire for Persons with Mental Retardation (DMR)

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12 December 2020

High dosage of ascorbic acid and alpha-tocopherol is not useful for diminishing oxidative stress and DNA damage in healthy elderly adults

1 reference

12 December 2020

Prevention of tocopherol-mediated peroxidation in ubiquinol-10-free human low density lipoprotein.

1 reference

12 December 2020

Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial

1 reference

12 December 2020

Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients: dose-response study and correlations with plasma levels

1 reference

12 December 2020

Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia

1 reference

12 December 2020

The behavior inventory for rating development (BIRD): assessments of reliability and factorial validity

1 reference

12 December 2020

Ribosome dysfunction is an early event in Alzheimer's disease.

1 reference

12 December 2020

The response of gamma vitamin E to varying dosages of alpha vitamin E plus vitamin C.

1 reference

12 December 2020

Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry.

1 reference

12 December 2020

Antioxidant vitamin supplement use and risk of dementia or Alzheimer's disease in older adults

1 reference

12 December 2020

Stress, aging, and neurodegenerative disorders. Molecular mechanisms

1 reference

12 December 2020

Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction

1 reference

12 December 2020

Identifiers

DOI

10.1002/AJMG.A.34114

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21739598%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21739598%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

21739598

1 reference