β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment (Q87843093)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

3 references

23 July 2020

27 January 2021

4 February 2021

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

2 references

23 July 2020

4 February 2021

genetic predisposition to disease

1 reference

23 July 2020

insulin-secreting cells

1 reference

27 January 2021

Philippe A Halban

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Kenneth S Polonsky

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Meredith A Hawkins

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Kieren J Mather

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Alvin C Powers

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Christopher J Rhodes

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Lori Sussel

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Gordon C Weir

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

publication date

8 May 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 June 2014

3 references

23 July 2020

27 January 2021

4 February 2021

5 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

23 July 2020

10 September 2020

27 January 2021

4 February 2021

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

page(s)

1751-1758

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial-NoDerivatives

17 March 2020

copyright license

3 references

23 July 2020

27 January 2021

4 February 2021

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

1 reference

12 December 2020

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

1 reference

12 December 2020

Effects of gastric bypass surgery in patients with type 2 diabetes and only mild obesity

1 reference

12 December 2020

Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1.

1 reference

12 December 2020

Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus

1 reference

12 December 2020

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets

1 reference

12 December 2020

miR-375 maintains normal pancreatic alpha- and beta-cell mass

1 reference

12 December 2020

Glucolipotoxicity of the pancreatic beta cell.

1 reference

12 December 2020

Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery

1 reference

12 December 2020

Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure

1 reference

12 December 2020

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

1 reference

12 December 2020

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1

1 reference

12 December 2020

The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects

1 reference

12 December 2020

Pancreatic beta-cell mass in European subjects with type 2 diabetes

1 reference

12 December 2020

Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin

1 reference

12 December 2020

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

1 reference

12 December 2020

Genome-wide analysis of histone modifications in human pancreatic islets

1 reference

12 December 2020

Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: how markers of β-cell loss may assist.

1 reference

12 December 2020

Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

1 reference

12 December 2020

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

1 reference

12 December 2020

A pancreatic islet-specific microRNA regulates insulin secretion

1 reference

12 December 2020

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss

1 reference

12 December 2020

A multisite study of long-term remission and relapse of type 2 diabetes mellitus following gastric bypass.

1 reference

12 December 2020

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

1 reference

12 December 2020

Type 2 diabetes as an inflammatory disease

1 reference

12 December 2020

Effects of metformin, metformin plus rosiglitazone, and metformin plus lifestyle on insulin sensitivity and β-cell function in TODAY.

1 reference

12 December 2020

Are we overestimating the loss of beta cells in type 2 diabetes?

1 reference

12 December 2020

Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes

1 reference

12 December 2020

Metabolic surgery for type 2 diabetes

1 reference

12 December 2020

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

1 reference

12 December 2020

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study

1 reference

12 December 2020

Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study

1 reference

12 December 2020

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

1 reference

12 December 2020

Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies

1 reference

12 December 2020

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

1 reference

12 December 2020

Prevention of diabetes with pioglitazone in ACT NOW: physiologic correlates

1 reference

12 December 2020

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

1 reference

12 December 2020

Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes

1 reference

12 December 2020

Islet β cell mass in diabetes and how it relates to function, birth, and death

1 reference

12 December 2020

Parental transmission of type 2 diabetes: the Framingham Offspring Study

1 reference

12 December 2020

Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes

1 reference

12 December 2020

Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci

1 reference

12 December 2020

Nationwide cohort study of post-gastric bypass hypoglycaemia including 5,040 patients undergoing surgery for obesity in 1986-2006 in Sweden

1 reference

12 December 2020

Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats.

1 reference

12 December 2020

Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

1 reference

12 December 2020

Targeting inflammation in the treatment of type 2 diabetes

1 reference

12 December 2020

Beta cell function following 1 year vildagliptin or placebo treatment and after 12 week washout in drug-naive patients with type 2 diabetes and mild hyperglycaemia: a randomised controlled trial

1 reference

12 December 2020

Imaging of β-cell mass and insulitis in insulin-dependent (Type 1) diabetes mellitus

1 reference

12 December 2020

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

1 reference

12 December 2020

Fluorescent exendin-4 derivatives for pancreatic β-cell analysis

1 reference

12 December 2020

The genetics of type 2 diabetes and its clinical relevance

1 reference

12 December 2020

Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.

1 reference

12 December 2020

The genetic and epigenetic basis of type 2 diabetes and obesity

1 reference

12 December 2020

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

1 reference

12 December 2020

Diabetes in old male offspring of rat dams fed a reduced protein diet.

1 reference

12 December 2020

Metabolic stress, IAPP and islet amyloid

1 reference

12 December 2020

Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

1 reference

12 December 2020

The stunned beta cell: a brief history

1 reference

12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

12 December 2020

Effects of exenatide on measures of β-cell function after 3 years in metformin-treated patients with type 2 diabetes

1 reference

12 December 2020

Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules

1 reference

12 December 2020

Family history of type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth

1 reference

12 December 2020

Gastric bypass and banding equally improve insulin sensitivity and β cell function

1 reference

12 December 2020

Regression from pre-diabetes to normal glucose regulation in the diabetes prevention program

1 reference

12 December 2020

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

1 reference

12 December 2020

Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.

1 reference

12 December 2020

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

1 reference

12 December 2020

Minireview: Hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery

1 reference

12 December 2020

Inactivation of specific β cell transcription factors in type 2 diabetes

1 reference

12 December 2020

Finding the missing heritability of complex diseases

1 reference

12 December 2020

Circulating microRNAs as novel biomarkers for diabetes mellitus

1 reference

12 December 2020

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

1 reference

12 December 2020

Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity

1 reference

12 December 2020

In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes?

1 reference

12 December 2020

Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial.

1 reference

12 December 2020

Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog

1 reference

12 December 2020

Current evidence for a role of GLP-1 in Roux-en-Y gastric bypass-induced remission of type 2 diabetes.

1 reference

12 December 2020

Five stages of evolving beta-cell dysfunction during progression to diabetes

1 reference

12 December 2020

One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial

1 reference

12 December 2020

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

1 reference

12 December 2020

Islets in type 2 diabetes: in honor of Dr. Robert C. Turner

1 reference

12 December 2020

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

1 reference

12 December 2020

Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1alpha gene mutations: evidence for pharmacogenetics in diabetes

1 reference

12 December 2020

Epigenomic plasticity enables human pancreatic α to β cell reprogramming.

1 reference

12 December 2020

Formation of a human β-cell population within pancreatic islets is set early in life

1 reference

12 December 2020

Identifiers

DOI

10.2337/DC14-0396

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24812433%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

24812433

1 reference