ADAMTS proteins in human disorders (Q89049490)

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30 March 2020

title

ADAMTS proteins in human disorders (English)

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2

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30 March 2020

author name string

Timothy J Mead

series ordinal

1

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publication date

6 June 2018

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volume

71-72

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30 March 2020

page(s)

225-239

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The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

30 March 2020

cites work

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12 December 2020

Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity

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12 December 2020

Preclinical and clinical studies of MMP inhibitors in cancer

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12 December 2020

Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene

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12 December 2020

Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

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12 December 2020

Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases

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12 December 2020

Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis

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12 December 2020

Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura

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12 December 2020

Cartilage damage by matrix degradation products: fibronectin fragments.

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12 December 2020

Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix

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12 December 2020

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

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12 December 2020

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12 December 2020

Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1

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12 December 2020

Aggrecan protects cartilage collagen from proteolytic cleavage

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12 December 2020

ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases

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12 December 2020

ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain

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12 December 2020

ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome

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12 December 2020

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

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12 December 2020

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

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12 December 2020

ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms

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12 December 2020

Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis

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12 December 2020

Putative susceptibility locus on chromosome 21q for lumbar disc disease (LDD) in the Finnish population

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12 December 2020

Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide

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12 December 2020

ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis

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12 December 2020

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

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12 December 2020

ADAMTS13 activity to antigen ratio in physiological and pathological conditions associated with an increased risk of thrombosis

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12 December 2020

Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains

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12 December 2020

Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure*

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12 December 2020

Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study

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12 December 2020

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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12 December 2020

Genome-wide association analysis identifies 20 loci that influence adult height

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12 December 2020

Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D

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12 December 2020

Drug insight: aggrecanases as therapeutic targets for osteoarthritis.

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12 December 2020

ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation

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12 December 2020

Characterization of proADAMTS5 processing by proprotein convertases.

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12 December 2020

ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries

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12 December 2020

Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia

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12 December 2020

A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated ectopia lentis

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12 December 2020

Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups

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12 December 2020

Genetic and molecular aspects of acromelic dysplasia

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12 December 2020

Positional identification of variants of Adamts16 linked to inherited hypertension

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12 December 2020

Lower levels of ADAMTS13 are associated with cardiovascular disease in young patients

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12 December 2020

Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene.

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12 December 2020

Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients

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12 December 2020

Association between genetic variation at the ADAMTS13 locus and ischemic stroke

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12 December 2020

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

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12 December 2020

Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature

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12 December 2020

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

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12 December 2020

ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation

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12 December 2020

ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells

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12 December 2020

Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women

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12 December 2020

Reduced ADAMTS13 in children with severe meningococcal sepsis is associated with severity and outcome

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12 December 2020

A novel ADAMTSL4 mutation in autosomal recessive ectopia lentis et pupillae

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12 December 2020

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

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12 December 2020

Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation

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12 December 2020

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

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12 December 2020

ADAMTSL3 as a candidate gene for schizophrenia: gene sequencing and ultra-high density association analysis by imputation

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12 December 2020

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

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12 December 2020

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

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12 December 2020

Mutations in the TGFβ binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias

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12 December 2020

Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function

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12 December 2020

The ADAMTS(L) family and human genetic disorders

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12 December 2020

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

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12 December 2020

ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis

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12 December 2020

Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction

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12 December 2020

Microenvironmental regulation by fibrillin-1

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12 December 2020

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

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12 December 2020

Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis

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12 December 2020

A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke

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12 December 2020

A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module

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12 December 2020

PPARG2 Pro12Ala and ADAMTS9 rs4607103 as “insulin resistance loci” and “insulin secretion loci” in Italian individuals. The GENFIEV study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4

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12 December 2020

ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant

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12 December 2020

Seven new loci associated with age-related macular degeneration

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12 December 2020

Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction

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12 December 2020

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

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12 December 2020

The syndrome of microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) is caused by mutations in ADAMTS18

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12 December 2020

Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis

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12 December 2020

Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia

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12 December 2020

Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population

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12 December 2020

Copy number variants in patients with short stature.

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12 December 2020

Genome-wide association study of gene by smoking interactions in coronary artery calcification

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12 December 2020

Altered gene expression in dry age-related macular degeneration suggests early loss of choroidal endothelial cells

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12 December 2020

A genome-wide association study for canine cryptorchidism in Siberian Huskies.

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12 December 2020

Thrombotic thrombocytopenic purpura: basic pathophysiology and therapeutic strategies

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12 December 2020

ADAMTS9locus associates with increased risk of wet AMD

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12 December 2020

CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation

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12 December 2020

Genetics of lymphatic anomalies

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12 December 2020

Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure

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12 December 2020

Genomic scan reveals loci under altitude adaptation in Tibetan and Dahe pigs.

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12 December 2020

Genetic susceptibility of lumbar degenerative disc disease in young Indian adults

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12 December 2020

Genetic contributions to urgency urinary incontinence in women

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12 December 2020

ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura

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12 December 2020

ADAMTS proteases and cancer

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12 December 2020

Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice

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12 December 2020

ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.

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12 December 2020

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics

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12 December 2020

Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate

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12 December 2020

Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification

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12 December 2020

The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology

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12 December 2020

Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction

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12 December 2020

Metalloproteinases: A parade of functions in matrix biology and an outlook for the future

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12 December 2020

ADAMTS proteins as modulators of microfibril formation and function

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12 December 2020

A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk.

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12 December 2020

A genome-wide association study of suicidal behavior

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12 December 2020

ADAMTS7 locus confers high cross-race risk for development of coronary atheromatous plaque.

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12 December 2020

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

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12 December 2020

Pathogenicity of Anti-ADAMTS13 Autoantibodies in Acquired Thrombotic Thrombocytopenic Purpura.

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12 December 2020

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis

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12 December 2020

Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene

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12 December 2020

A Novel Genome-Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17.

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12 December 2020

A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia

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12 December 2020

Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets.

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12 December 2020

ADAMTS genes and the risk of cerebral aneurysm

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12 December 2020

Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA).

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12 December 2020

Whole-exome sequencing in individuals with multiple cardiovascular risk factors and normal coronary arteries

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12 December 2020

Association of ADAMTS-7 Levels with Cardiac Function in a Rat Model of Acute Myocardial Infarction

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12 December 2020

Preclinical assessment of a new recombinant ADAMTS-13 drug product (BAX930) for the treatment of thrombotic thrombocytopenic purpura

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12 December 2020

Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease

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12 December 2020

Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome.

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12 December 2020

Update on ADAMTS13 and VWF in cardiovascular and hematological disorders

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12 December 2020

Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease

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12 December 2020

Rare and low-frequency coding variants alter human adult height

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12 December 2020

Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease.

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12 December 2020

The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population

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12 December 2020

Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

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12 December 2020

Genome-wide association study for birth, weaning and yearling weight in Colombian Brahman cattle

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12 December 2020

ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis.

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12 December 2020

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

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12 December 2020

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

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12 December 2020

Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians.

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12 December 2020

Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura

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12 December 2020

Loss of ADAMTS3 activity causes Hennekam lymphangiectasia-lymphedema syndrome 3.

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12 December 2020

GWAS on prolonged gestation (post-term birth): analysis of successive Finnish birth cohorts

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12 December 2020

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

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12 December 2020

Genetic Variation at the ADAMTS7 Locus is Associated With Reduced Severity of Coronary Artery Disease

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12 December 2020

Recombinant ADAMTS 13 in thrombotic thrombocytopenic purpura

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12 December 2020

Novel Myopia Genes and Pathways Identified From Syndromic Forms of Myopia

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12 December 2020

Whole Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.

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12 December 2020

Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.

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12 December 2020

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.

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12 December 2020

The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.

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12 December 2020

Role of ADAMTS (A Disintegrin and Metalloproteinase With Thrombospondin Motifs)-5 in Aortic Dilatation and Extracellular Matrix Remodeling.

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12 December 2020

Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families

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12 December 2020

10.1016/J.MATBIO.2018.06.002

Identifiers

DOI

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30 March 2020

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30 March 2020

PubMed publication ID

29885460

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