Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway (Q89173731)

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scientific article published on 01 June 2018

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English	Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway	scientific article published on 01 June 2018

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6022469

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1 April 2020

title

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway (English)

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6022469

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1 April 2020

main subject

reperfusion injury

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autophagy

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author name string

Jin-Feng Wang

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1

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6022469

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1 April 2020

Zhi-Gang Mei

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2

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6022469

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1 April 2020

Yang Fu

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3

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6022469

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Song-Bai Yang

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4

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6022469

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Shi-Zhong Zhang

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5

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6022469

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1 April 2020

Wei-Feng Huang

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6

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1 April 2020

Li Xiong

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7

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6022469

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Hua-Jun Zhou

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8

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6022469

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1 April 2020

Wei Tao

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9

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PMC publication ID

6022469

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1 April 2020

Zhi-Tao Feng

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10

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6022469

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1 April 2020

publication date

1 June 2018

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1 April 2020

published in

Neural Regeneration Research

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6022469

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1 April 2020

volume

13

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6022469

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1 April 2020

issue

6

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6022469

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1 April 2020

page(s)

989-998

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6022469

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1 April 2020

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats

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ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.

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Chinese medicine neuroaid efficacy on stroke recovery: a double-blind, placebo-controlled, randomized study

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Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition

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Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway

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Puerarin attenuates cerebral damage by improving cerebral microcirculation in spontaneously hypertensive rats

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Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway

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Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29926825

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Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy

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https://pubmed.ncbi.nlm.nih.gov/29926825

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Dissecting Xuesaitong's mechanisms on preventing stroke based on the microarray and connectivity map.

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based on heuristic

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Puerarin Attenuates Anoxia/Reoxygenation Injury Through Enhancing Bcl-2 Associated Athanogene 3 Expression, a Modulator of Apoptosis and Autophagy

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Resveratrol protects CA1 neurons against focal cerebral ischemic reperfusion-induced damage via the ERK-CREB signaling pathway in rats

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N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway

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12 December 2020

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inferred from PubMed ID database lookup

Inhibition of AMP-activated protein kinase alleviates focal cerebral ischemia injury in mice: Interference with mTOR and autophagy

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inferred from PubMed ID database lookup

Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die

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12 December 2020

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Cortical spreading depression preconditioning mediates neuroprotection against ischemic stroke by inducing AMP-activated protein kinase-dependent autophagy in a rat cerebral ischemic/reperfusion injury model

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Efficacy and safety of puerarin injection in curing acute ischemic stroke: A meta-analysis of randomized controlled trials

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29926825

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Puerarin provides a neuroprotection against transient cerebral ischemia by attenuating autophagy at the ischemic penumbra in neurons but not in astrocytes.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29926825

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats

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12 December 2020

based on heuristic

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Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells

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12 December 2020

based on heuristic

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Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway

1 reference

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12 December 2020

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Increased arterial stiffness is an independent risk factor for hemorrhagic transformation in ischemic stroke undergoing thrombolysis

1 reference

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Ischemia-reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies.

1 reference

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reference URL

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12 December 2020

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Identifiers

DOI

10.4103/1673-5374.233441

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Europe PubMed Central

PMC publication ID

6022469

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29926825%20AND%20SRC:MED&resulttype=core&format=json

retrieved

1 April 2020

PMC publication ID

6022469

1 reference

stated in

Europe PubMed Central

PMC publication ID

6022469

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29926825%20AND%20SRC:MED&resulttype=core&format=json

retrieved

1 April 2020

PubMed publication ID

29926825

1 reference

stated in

Europe PubMed Central

PMC publication ID

6022469

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29926825%20AND%20SRC:MED&resulttype=core&format=json

retrieved

1 April 2020

 

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