Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway (Q97420785)

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scientific article published on 19 June 2020

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English	Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway	scientific article published on 19 June 2020

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scholarly article

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16 July 2020

Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway (English)

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16 July 2020

acute kidney injury

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Xiangru Li

1

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16 July 2020

Zhenhua Hao

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16 July 2020

Xiaorong Liu

3

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16 July 2020

Wei Li

4

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16 July 2020

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19 June 2020

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16 July 2020

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16 July 2020

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16 July 2020

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19 June 2020

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Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

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Complement Nomenclature-Deconvoluted

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Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS

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Altered Peripheral Blood Leucocyte Phenotype and Responses in Healthy Individuals with Homozygous Deletion of FHR1 and FHR3 Genes

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Shiga Toxin as a Potential Trigger of CFHR1 Deletion-Associated Thrombotic Microangiopathy

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Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

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Characterization of genetic predisposition and autoantibody profile in atypical haemolytic-uraemic syndrome.

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The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential

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Haemostasis and innate immunity - a complementary relationship: A review of the intricate relationship between coagulation and complement pathways

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Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins

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10 February 2021

Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma

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10 February 2021

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation

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Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014.

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Mini review: A unique case of crescentic C3 glomerulonephritis.

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Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation.

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Association among Complement Factor H Autoantibodies, Deletions of CFHR, and the Risk of Atypical Hemolytic Uremic Syndrome

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10 February 2021

The complement factor H-related proteins

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10 February 2021

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

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10 February 2021

Fine Mapping Implicates a Deletion of CFHR1 and CFHR3 in Protection from IgA Nephropathy in Han Chinese.

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10 February 2021

Factor H-related proteins determine complement-activating surfaces

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10 February 2021

Carboxypeptidase B2 deficiency reveals opposite effects of complement C3a and C5a in a murine polymicrobial sepsis model

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10 February 2021

Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth

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10 February 2021

Atypical aHUS: State of the art.

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10 February 2021

Of mice and men: The factor H protein family and complement regulation.

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10 February 2021

New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases

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10 February 2021

Human factor H-related protein 2 (CFHR2) regulates complement activation

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10 February 2021

Deficiency in complement factor B.

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10 February 2021

Complement factor H related proteins (CFHRs)

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10 February 2021

Functional anatomy of complement factor H.

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10 February 2021

Determining the population frequency of the CFHR3/CFHR1 deletion at 1q32.

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10 February 2021

Dimerization of complement factor H-related proteins modulates complement activation in vivo

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Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome

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10 February 2021

The role of complement system in septic shock

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Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility

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10 February 2021

An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

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Complement: a key system for immune surveillance and homeostasis

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Endotoxins and other sepsis triggers

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Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

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Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

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10 February 2021

The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome.

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Complexity of complement activation in sepsis

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The alternative complement pathway revisited

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Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement

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Properdin deficiency in a boy with fulminant meningococcal septic shock

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Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein.

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1 reference

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1 reference

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10 February 2021

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10.3389/FIMMU.2020.01123

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Europe PubMed Central

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16 July 2020

PMC publication ID

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16 July 2020

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16 July 2020

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