Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer's Disease (Q90521382)

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14 April 2020

review article

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title

Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer's Disease (English)

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14 April 2020

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4

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14 April 2020

Jordi Llop

5

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14 April 2020

Isabel Cardoso

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14 April 2020

author name string

Tiago Gião

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14 April 2020

Joana Saavedra

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14 April 2020

Ellen Cotrina

3

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14 April 2020

Gemma Arsequell

6

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14 April 2020

publication date

18 March 2020

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International Journal of Molecular Sciences

14 April 2020

published in

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14 April 2020

volume

21

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14 April 2020

issue

6

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Creative Commons Attribution 4.0 International

14 April 2020

copyright license

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18 March 2020

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cites work

Hormonal and nutritional status: Critical conditions for endemic goiter epidemiology?

1 reference

12 December 2020

Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A

1 reference

12 December 2020

The role of transthyretin in the transport of thyroid hormone to cerebrospinal fluid and brain

1 reference

12 December 2020

Recent achievements in studies on thyroid hormone-binding proteins

1 reference

12 December 2020

Plasma transthyretin. Tissue sites of degradation and turnover in the rat

1 reference

12 December 2020

Transthyretin: a choroid plexus-specific transport protein in human brain. The 1986 S. Weir Mitchell award

1 reference

12 December 2020

Demonstration of transthyretin mRNA in the brain and other extrahepatic tissues in the rat.

1 reference

12 December 2020

The amino acid sequence of human plasma prealbumin.

1 reference

12 December 2020

Influence of age and sex on prealbumin levels

1 reference

12 December 2020

The contribution of thyroxine-binding prealbumin to the binding of thyroxine in human serum, as assessed by immunoadsorption

1 reference

12 December 2020

The Interaction of Thyroxine with Human Plasma Prealbumin and with the Prealbumin-Retinol-binding Protein Complex

1 reference

12 December 2020

Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. Definition of molecular abnormality in transthyretin (prealbumin).

1 reference

12 December 2020

The concentration of prealbumin in cerebrospinal fluid (CSF), indicator of CSF circulation disorders

1 reference

12 December 2020

Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion

1 reference

12 December 2020

Plasma retinol-binding protein

1 reference

12 December 2020

Binding of thyroid hormones and analogues to the human plasma protein prealbumin.

1 reference

12 December 2020

Thickening of the basement membrane of cortical capillaries in Alzheimer's disease.

1 reference

12 December 2020

Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein

1 reference

12 December 2020

Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination

1 reference

12 December 2020

Transthyretin sequesters amyloid beta protein and prevents amyloid formation

1 reference

12 December 2020

Transthyretin expression in the rat brain: effect of thyroid functional state and role in thyroxine transport

1 reference

12 December 2020

Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro.

1 reference

12 December 2020

Sequestration of amyloid beta-peptide

1 reference

12 December 2020

The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex

1 reference

12 December 2020

Apolipoproteins E3 and E4 induce, and transthyretin prevents accumulation of the Alzheimer's beta-amyloid peptide in cultured vascular smooth muscle cells.

1 reference

12 December 2020

Interaction of transthyretin with amyloid beta-protein: binding and inhibition of amyloid formation

1 reference

12 December 2020

Transthyretin gene in Alzheimer's disease patients.

1 reference

12 December 2020

Inhibiting transthyretin amyloid fibril formation via protein stabilization

1 reference

12 December 2020

Cerebrospinal fluid transthyretin: aging and late onset Alzheimer's disease

1 reference

12 December 2020

Comparative stability and clearance of [Met30]transthyretin and [Met119]transthyretin

1 reference

12 December 2020

Apolipoprotein E, transthyretin and actin in the CSF of Alzheimer's patients: relation with the senile plaques and cytoskeleton biochemistry

1 reference

12 December 2020

The crystal structure of amyloidogenic Leu55 --> Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils

1 reference

12 December 2020

Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid

1 reference

12 December 2020

Comparative Studies of Two Transthyretin Variants with Protective Effects on Familial Amyloidotic Polyneuropathy: TTR R104H and TTR T119M

1 reference

12 December 2020

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

12 December 2020

Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants

1 reference

12 December 2020

An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured

1 reference

12 December 2020

Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.

1 reference

12 December 2020

Angiogenesis in health and disease

1 reference

12 December 2020

A peculiar form of peripheral neuropathy

1 reference

12 December 2020

Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative

1 reference

12 December 2020

Amyloidogenic and anti-amyloidogenic properties of recombinant transthyretin variants

1 reference

12 December 2020

Structure of the Val122Ile variant transthyretin - a cardiomyopathic mutant

1 reference

12 December 2020

Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

1 reference

12 December 2020

The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors.

1 reference

12 December 2020

Amyloid neuropathy: a retrospective study of 35 peripheral nerve biopsies

1 reference

12 December 2020

Invertebrate models of Alzheimer's disease

1 reference

12 December 2020

Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

1 reference

12 December 2020

Transthyretin knockouts are a new mouse model for increased neuropeptide Y.

1 reference

12 December 2020

Selection of peptides binding to the amyloid b-protein reveals potential inhibitors of amyloid formation

1 reference

12 December 2020

AN ELECTROPHORETIC STUDY OF THE PROTEIN COMPONENTS IN CEREBROSPINAL FLUID AND THEIR RELATIONSHIP TO THE SERUM PROTEINS.

1 reference

12 December 2020

Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver

1 reference

12 December 2020

1 reference

12 December 2020

Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).

1 reference

12 December 2020

Transthyretin influences spatial reference memory.

1 reference

12 December 2020

Transthyretin enhances nerve regeneration

1 reference

12 December 2020

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity

1 reference

12 December 2020

Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice

1 reference

12 December 2020

Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity.

1 reference

12 December 2020

Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study

1 reference

12 December 2020

Quantitative analysis of transthyretin, tau and amyloid-beta in patients with dementia.

1 reference

12 December 2020

Transthyretin is up-regulated by sex hormones in mice liver.

1 reference

12 December 2020

Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor

1 reference

12 December 2020

17beta-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway.

1 reference

12 December 2020

Substrate specificity of transthyretin: identification of natural substrates in the nervous system

1 reference

12 December 2020

Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity.

1 reference

12 December 2020

Characterization of the Interaction of β-Amyloid with Transthyretin Monomers and Tetramers

1 reference

12 December 2020

CSF transthyretin neuroprotection in a mouse model of brain ischemia

1 reference

12 December 2020

Human serum transthyretin levels correlate inversely with Alzheimer's disease

1 reference

12 December 2020

Gender-dependent transthyretin modulation of brain amyloid-β levels: evidence from a mouse model of Alzheimer's disease

1 reference

12 December 2020

Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?

1 reference

12 December 2020

Plasma transthyretin as a candidate marker for Alzheimer's disease

1 reference

12 December 2020

Transthyretin is a metallopeptidase with an inducible active site

1 reference

12 December 2020

Identification of beta-amyloid-binding sites on transthyretin

1 reference

12 December 2020

Transthyretin decrease in plasma of MCI and AD patients: investigation of mechanisms for disease modulation.

1 reference

12 December 2020

Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease

1 reference

12 December 2020

Genetic stabilization of transthyretin, cerebrovascular disease, and life expectancy.

1 reference

12 December 2020

Transthyretin and the human placenta

1 reference

12 December 2020

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

1 reference

12 December 2020

Resveratrol increases cerebral glycogen synthase kinase phosphorylation as well as protein levels of drebrin and transthyretin in mice: an exploratory study

1 reference

12 December 2020

Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells

1 reference

12 December 2020

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

1 reference

12 December 2020

Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model

1 reference

12 December 2020

Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro

1 reference

12 December 2020

BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease

1 reference

12 December 2020

The Aβ-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain.

1 reference

12 December 2020

The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.

1 reference

12 December 2020

Transthyretin Induces Insulin-like Growth Factor I Nuclear Translocation Regulating Its Levels in the Hippocampus

1 reference

12 December 2020

Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease

1 reference

12 December 2020

Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice

1 reference

12 December 2020

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

1 reference

12 December 2020

Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

Clearance systems in the brain-implications for Alzheimer disease

1 reference

12 December 2020

Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor

1 reference

12 December 2020

Transthyretin participates in beta-amyloid transport from the brain to the liver--involvement of the low-density lipoprotein receptor-related protein 1?

1 reference

12 December 2020

Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Val30Met: A phase III, open-label study

1 reference

12 December 2020

Transthyretin Suppresses Amyloid-β Secretion by Interfering with Processing of the Amyloid-β Protein Precursor

1 reference

12 December 2020

Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease

1 reference

12 December 2020

Resveratrol administration increases Transthyretin protein levels ameliorating AD features - importance of transthyretin tetrameric stability

1 reference

12 December 2020

Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia

1 reference

12 December 2020

Rare Genetic Variants of the Transthyretin Gene Are Associated with Alzheimer's Disease in Han Chinese

1 reference

12 December 2020

Transthyretin represses neovascularization in diabetic retinopathy

1 reference

12 December 2020

Maternal Circulating Transthyretin Level Is Longitudinally Associated With Increased Risk of Gestational Diabetes Mellitus: It Is Not Just an Indicator of Nutritional Status.

1 reference

12 December 2020

Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade

1 reference

12 December 2020

Transthyretin stability is critical in assisting beta amyloid clearance- Relevance of transthyretin stabilization in Alzheimer's disease.

1 reference

12 December 2020

Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal

1 reference

12 December 2020

Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia

1 reference

12 December 2020

Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis

1 reference

12 December 2020

Transthyretin Exerts Pro-Apoptotic Effects in Human Retinal Microvascular Endothelial Cells Through a GRP78-Dependent Pathway in Diabetic Retinopathy.

1 reference

12 December 2020

Inhibition of amyloid beta fibril formation by monomeric human transthyretin

1 reference

12 December 2020

Transthyretin Interferes with Aβ Amyloid Formation by Redirecting Oligomeric Nuclei into Non-Amyloid Aggregates

1 reference

12 December 2020

The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ42 and Alzheimer Amyloid Plaques

1 reference

12 December 2020

Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells

1 reference

12 December 2020

Blood-brain and blood-cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice

1 reference

12 December 2020

Identification of transthyretin as a novel interacting partner for the δ subunit of GABAA receptors

1 reference

12 December 2020

A molecular mechanism for transthyretin amyloidogenesis

1 reference

12 December 2020

Powering Amyloid Beta Degrading Enzymes: A Possible Therapy for Alzheimer's Disease

1 reference

12 December 2020

Plasma exchange for Alzheimer's disease Management by Albumin Replacement (AMBAR) trial: Study design and progress

1 reference

12 December 2020

The Amyloid Phenomenon and Its Significance in Biology and Medicine

1 reference

12 December 2020

Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?

1 reference

12 December 2020

Collagen type IV in brain vessels of an AD mouse model: modulation by transthyretin?

1 reference

12 December 2020

Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD

1 reference

12 December 2020

Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro

1 reference

12 December 2020

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

1 reference

12 December 2020

Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery

1 reference

12 December 2020