A zebrafish hox gene acts before gastrulation to specify the hemangioblast (Q92014006)

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26 April 2020

title

A zebrafish hox gene acts before gastrulation to specify the hemangioblast (English)

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26 April 2020

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1

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26 April 2020

author name string

Mark Featherstone

series ordinal

2

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26 April 2020

publication date

17 April 2020

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26 April 2020

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26 April 2020

page(s)

e23363

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The role of HOX genes in normal hematopoiesis and acute leukemia.

26 April 2020

cites work

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Zebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesis

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The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo

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cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes

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Intraembryonic hematopoietic cell migration during vertebrate development

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The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver

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Acquisition of Hox codes during gastrulation and axial elongation in the mouse embryo.

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Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

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Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: evidence for unique and redundant function

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Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed

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Collinear activation of Hoxb genes during gastrulation is linked to mesoderm cell ingression.

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Hox genes in time and space during vertebrate body formation

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Caudal genes in blood development and leukemia

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BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway

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Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex

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Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

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meis1 regulates the development of endothelial cells in zebrafish

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Hox cofactors in vertebrate development

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Advanced Zebrafish Transgenesis with Tol2 and Application for Cre/lox Recombination Experiments

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At the base of colinear Hox gene expression: cis-features and trans-factors orchestrating the initial phase of Hox cluster activation

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The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins

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MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation

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Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex

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Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif

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Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and HOXD4

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The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis.

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Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation

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The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages

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A proline-rich transcriptional activation domain in murine HOXD-4 (HOX-4.2).

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Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo

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Genetic compensation induced by deleterious mutations but not gene knockdowns.

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Residues flanking the HOX YPWM motif contribute to cooperative interactions with PBX

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PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins

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Ectopic expression of Hoxb4a in hemangioblasts promotes hematopoietic development in early embryogenesis of zebrafish

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7 January 2021

Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes

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7 January 2021

Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells

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7 January 2021

High-resolution in situ hybridization to whole-mount zebrafish embryos

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7 January 2021

Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

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7 January 2021

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

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7 January 2021

Identification of hoxb1b downstream genes: hoxb1b as a regulatory factor controlling transcriptional networks and cell movement during zebrafish gastrulation

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7 January 2021

A homeo domain protein lacking specific side chains of helix 3 can still bind DNA and direct transcriptional repression

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7 January 2021

A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula

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7 January 2021

Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation.

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7 January 2021

The initiation of Hox gene expression in Xenopus laevis is controlled by Brachyury and BMP-4.

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The zebrafish hoxDb cluster has been reduced to a single microRNA

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7 January 2021

RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation

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7 January 2021

Identifiers

DOI

10.1002/DVG.23363

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26 April 2020

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