Direct visualization of cAMP signaling in primary cilia reveals up-regulation of ciliary GPCR activity following Hedgehog activation (Q92381421)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31142652%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

title

Direct visualization of cAMP signaling in primary cilia reveals up-regulation of ciliary GPCR activity following Hedgehog activation (English)

1 reference

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29 April 2020

author name string

Jason Y Jiang

1

1 reference

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29 April 2020

Jeffrey L Falcone

2

1 reference

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29 April 2020

Silvana Curci

3

1 reference

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29 April 2020

Aldebaran M Hofer

4

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29 April 2020

publication date

29 May 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31142652%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

29 April 2020

published in

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29 April 2020

volume

116

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29 April 2020

issue

24

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29 April 2020

page(s)

12066-12071

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The role of 5 HT6-receptor antagonists in Alzheimer's disease: an update

29 April 2020

cites work

1 reference

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Hedgehog pathway and smoothened inhibitors in cancer therapies.

17 February 2021

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Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides

17 February 2021

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New ADCY3 Variants Dance in Obesity Etiology

17 February 2021

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Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium.

17 February 2021

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G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.

17 February 2021

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Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

17 February 2021

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Identification of clustered phosphorylation sites in PKD2L1: how PKD2L1 channel activation is regulated by cyclic adenosine monophosphate signaling pathway

17 February 2021

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Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease

17 February 2021

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Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer's disease by regulating cilia function

17 February 2021

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5-HT6 receptor blockade regulates primary cilia morphology in striatal neurons.

17 February 2021

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Primary Cilia and Mammalian Hedgehog Signaling

17 February 2021

1 reference

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Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics

17 February 2021

1 reference

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The native TRPP2-dependent channel of murine renal primary cilia

17 February 2021

1 reference

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Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Type 3 Adenylyl Cyclase and Somatostatin Receptor 3 Expression Persists in Aged Rat Neocortical and Hippocampal Neuronal Cilia

17 February 2021

1 reference

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A novel biosensor to study cAMP dynamics in cilia and flagella

17 February 2021

1 reference

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The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Proteomics of Primary Cilia by Proximity Labeling

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Ciliary adenylyl cyclases control the Hedgehog pathway

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Fourth-generation epac-based FRET sensors for cAMP feature exceptional brightness, photostability and dynamic range: characterization of dedicated sensors for FLIM, for ratiometry and with high affinity

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Generation and functions of second messengers microdomains.

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Analysis of soluble protein entry into primary cilia using semipermeabilized cells

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma

17 February 2021

1 reference

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Primary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengers

17 February 2021

1 reference

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G-protein-coupled receptors, Hedgehog signaling and primary cilia

17 February 2021

1 reference

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The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis

17 February 2021

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Direct recording and molecular identification of the calcium channel of primary cilia.

17 February 2021

1 reference

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Primary cilia are specialized calcium signalling organelles

17 February 2021

1 reference

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Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier

17 February 2021

1 reference

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Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia.

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin.

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Arborization of dendrites by developing neocortical neurons is dependent on primary cilia and type 3 adenylyl cyclase.

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base.

17 February 2021

1 reference

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Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion

17 February 2021

1 reference

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"cAMP sponge": a buffer for cyclic adenosine 3', 5'-monophosphate

17 February 2021

1 reference

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Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells

17 February 2021

1 reference

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5-HT6 receptors: a novel target for cognitive enhancement

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Small molecule modulation of Smoothened activity

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

The Hedgehog and Wnt signalling pathways in cancer

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain

17 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6575585

17 February 2021

Identifiers

DOI

10.1073/PNAS.1819730116

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31142652%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31142652%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

PubMed publication ID

31142652

1 reference