Longevity-related molecular pathways are subject to midlife "switch" in humans (Q92554902)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31168962%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

title

Longevity-related molecular pathways are subject to midlife "switch" in humans (English)

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30 April 2020

1

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30 April 2020

Claude-Henry Volmar

2

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30 April 2020

Urho Kujala

8

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30 April 2020

Claes Wahlestedt

11

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7

Timo Törmäkangas

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30 April 2020

5

Sanjana Sood

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30 April 2020

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Hannah Crossland

3

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30 April 2020

Bethan E Phillips

4

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30 April 2020

Karolina J Janczura

6

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30 April 2020

William E Kraus

9

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30 April 2020

Philip J Atherton

10

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30 April 2020

publication date

6 June 2019

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30 April 2020

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30 April 2020

volume

18

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issue

4

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30 April 2020

page(s)

e12970

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mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.

30 April 2020

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STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy

11 February 2021

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Transcriptome profiling of aging Drosophila photoreceptors reveals gene expression trends that correlate with visual senescence

11 February 2021

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11 February 2021

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A Practical and Time-Efficient High-Intensity Interval Training Program Modifies Cardio-Metabolic Risk Factors in Adults with Risk Factors for Type II Diabetes.

11 February 2021

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Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

11 February 2021

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A dynamic ribosomal biogenesis response is not required for IGF-1-mediated hypertrophy of human primary myotubes.

11 February 2021

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The Dimensions, Dynamics, and Relevance of the Mammalian Noncoding Transcriptome

11 February 2021

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11 February 2021

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Key proteins and pathways that regulate lifespan

11 February 2021

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Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

11 February 2021

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In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state.

11 February 2021

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Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

11 February 2021

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Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss

11 February 2021

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Effects of exercise training alone vs a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: a randomised controlled trial

11 February 2021

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

11 February 2021

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Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness

11 February 2021

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Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB.

11 February 2021

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Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

11 February 2021

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iGEMS: an integrated model for identification of alternative exon usage events

11 February 2021

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HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc

11 February 2021

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Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality

11 February 2021

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Multiscale Embedded Gene Co-expression Network Analysis

11 February 2021

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Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

11 February 2021

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Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

11 February 2021

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Multiple sources of bias confound functional enrichment analysis of global -omics data

11 February 2021

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A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status

11 February 2021

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Interventions to Slow Aging in Humans: Are We Ready?

11 February 2021

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The effects of aerobic, resistance, and combination training on insulin sensitivity and secretion in overweight adults from STRRIDE AT/RT: a randomized trial

11 February 2021

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Mitochondrial and cytoplasmic ROS have opposing effects on lifespan

11 February 2021

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Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD.

11 February 2021

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Developmental regulation of human cortex transcription and its clinical relevance at single base resolution

11 February 2021

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TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB

11 February 2021

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Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

11 February 2021

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NetworkAnalyst--integrative approaches for protein-protein interaction network analysis and visual exploration

11 February 2021

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mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits

11 February 2021

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Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

11 February 2021

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Molecular networks of human muscle adaptation to exercise and age

11 February 2021

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mTORC2 controls actin polymerization required for consolidation of long-term memory.

11 February 2021

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Rapalogs and mTOR inhibitors as anti-aging therapeutics

11 February 2021

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Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

11 February 2021

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An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection

11 February 2021

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Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction. Hypothetical role of the adapter protein ECSIT in familial and sporadic Alzheimer's disease pathogenesis

11 February 2021

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Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

11 February 2021

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Spatio-temporal transcriptome of the human brain

11 February 2021

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Intrinsic aerobic capacity sets a divide for aging and longevity

11 February 2021

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Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies

11 February 2021

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The initial U3 snoRNA:pre-rRNA base pairing interaction required for pre-18S rRNA folding revealed by in vivo chemical probing

11 February 2021

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mTOR: from growth signal integration to cancer, diabetes and ageing

11 February 2021

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A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans

11 February 2021

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Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration.

11 February 2021

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Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

11 February 2021

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Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1.

11 February 2021

1 reference

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Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly

11 February 2021

1 reference

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Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data

11 February 2021

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Fluvastatin reduces the impact of diabetes on long-term outcome after coronary intervention--a Lescol Intervention Prevention Study (LIPS) substudy

11 February 2021

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Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging

11 February 2021

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Bioconductor: open software development for computational biology and bioinformatics

11 February 2021

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Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

11 February 2021

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Effects of Calcium-Channel Blockade in Older Patients with Diabetes and Systolic Hypertension

11 February 2021

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11 February 2021

Identifiers

DOI

10.1111/ACEL.12970

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31168962%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31168962%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

PubMed publication ID

31168962

1 reference