S Wikipedije, slobodne enciklopedije
Alkoholna dehidrogenaza 1 sa gvožđem je protein koji je kod ljudi kodiran genom ADHFE1 .[ 5]
Dužina polipeptidnog lanca je 467 aminokiselina , а molekulska težina 50.308 Da .[ 6]
10 20 30 40 50 MAAAARARVA YLLRQLQRAA CQCPTHSHTY SQAPGLSPSG KTTDYAFEMA VSNIRYGAAV TKEVGMDLKN MGAKNVCLMT DKNLSKLPPV QVAMDSLVKN GIPFTVYDNV RVEPTDSSFM EAIEFAQKGA FDAYVAVGGG STMDTCKAAN LYASSPHSDF LDYVSAPIGK GKPVSVPLKP LIAVPTTSGT GSETTGVAIF DYEHLKVKIG ITSRAIKPTL GLIDPLHTLH MPARVVANSG FDVLCHALES YTTLPYHLRS PCPSNPITRP AYQGSNPISD IWAIHALRIV AKYLKRAVRN PDDLEARSHM HLASAFAGIG FGNAGVHLCH GMSYPISGLV KMYKAKDYNV DHPLVPHGLS VVLTSPAVFT FTAQMFPERH LEMAEILGAD TRTARIQDAG LVLADTLRKF LFDLDVDDGL AAVGYSKADI PALVKGTLPQ ERVTKLAPCP QSEEDLAALF EASMKLY
Gen ADHFE1 kodira hidroksikiselinsku-oksokiselinsku transhidrogenazu (EC 1.1.99.24), koja je odgovorna za oksidaciju 4-hidroksibutirata u tkivima sisara .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000147576 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025911 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: Alcohol dehydrogenase, iron containing 1" . Pristupljeno 16. 6. 2017 .^ "UniProt, Q8IWW8" . Pristupljeno 13. 9. 2021 .^ Kardon T, Noël G, Vertommen D, Schaftingen EV (april 2006). "Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate". FEBS Letters . 580 (9): 2347–50. doi :10.1016/j.febslet.2006.02.082 . PMID 16616524 . S2CID 46525441 .
Deng Y, Wang Z, Gu S, Ji C, Ying K, Xie Y, Mao Y (oktobar 2002). "Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1)". DNA Sequence . 13 (5): 301–6. doi :10.1080/1042517021000011636 . PMID 12592711 . S2CID 24529446 . Lyon RC, Johnston SM, Panopoulos A, Alzeer S, McGarvie G, Ellis EM (mart 2009). "Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1". Chemico-Biological Interactions . 178 (1–3): 283–7. doi :10.1016/j.cbi.2008.10.025 . PMID 19013439 . Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (septembar 2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression" . PLOS ONE . 5 (9): e12862. Bibcode :2010PLoSO...512862H . doi :10.1371/journal.pone.0012862 PMC 2943476 PMID 20877624 . Tae CH, Ryu KJ, Kim SH, Kim HC, Chun HK, Min BH, Chang DK, Rhee PL, Kim JJ, Rhee JC, Kim YH (mart 2013). "Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation" . BMC Cancer . 13 : 142. doi :10.1186/1471-2407-13-142 . PMC 3618294 PMID 23517143 . 
