LRRC15

LRRC15
Identifikatori
Aliasi	LRRC15
Vanjski ID-jevi	MGI: 1921738 HomoloGene: 26080 GeneCards: LRRC15
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	194,369,743 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	30,102,074 bp
Ontologija gena
Molekularna funkcija	• fibronectin binding; • protein kinase inhibitor activity; • laminin binding; • collagen binding;
Ćelijska komponenta	• citoplazma; • integral component of membrane; • Egzosom; • membrana; • Vanćelijsko; • GO:0005578 Vanćelijski matriks; • collagen-containing extracellular matrix;
Biološki proces	• negative regulation of protein kinase activity; • cytokine-mediated signaling pathway; • negative regulation of receptor signaling pathway via JAK-STAT; • positive regulation of cell migration; • negative regulation of protein localization to plasma membrane;
	Izvori:Amigo / QuickGO
Ortolozi
	131578
	74488
	ENSG00000172061
	ENSMUSG00000052316
	Q8TF66
	Q80X72
	NM_130830; NM_001135057
	NM_028973
	NP_001128529; NP_570843
	NP_083249
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 15 sa leucinom bogatim ponavljanjem jest protein koji je kod ljudi kodiran genom LRRC15 sa hromosoma 3.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 581 aminokiselina, а molekulska težina 64.366 Da.^[6].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPLKHYLLLL	VGCQAWGAGL	AYHGCPSECT	CSRASQVECT	GARIVAVPTP
LPWNAMSLQI	LNTHITELNE	SPFLNISALI	ALRIEKNELS	RITPGAFRNL
GSLRYLSLAN	NKLQVLPIGL	FQGLDSLESL	LLSSNQLLQI	QPAHFSQCSN
LKELQLHGNH	LEYIPDGAFD	HLVGLTKLNL	GKNSLTHISP	RVFQHLGNLQ
VLRLYENRLT	DIPMGTFDGL	VNLQELALQQ	NQIGLLSPGL	FHNNHNLQRL
YLSNNHISQL	PPSVFMQLPQ	LNRLTLFGNS	LKELSPGIFG	PMPNLRELWL
YDNHISSLPD	NVFSNLRQLQ	VLILSRNQIS	FISPGAFNGL	TELRELSLHT
NALQDLDGNV	FRMLANLQNI	SLQNNRLRQL	PGNIFANVNG	LMAIQLQNNQ
LENLPLGIFD	HLGKLCELRL	YDNPWRCDSD	ILPLRNWLLL	NQPRLGTDTV
PVCFSPANVR	GQSLIIINVN	VAVPSVHVPE	VPSYPETPWY	PDTPSYPDTT
SVSSTTELTS	PVEDYTDLTT	IQVTDDRSVW	GMTQAQSGLA	IAAIVIGIVA
LACSLAACVG	CCCCKKRSQA	VLMQMKAPNE	C

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172061 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052316 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Leucine rich repeat containing 15".
^ "UniProt, Q8TF66" (jezik: engleski). Pristupljeno 8. 11. 2021.

Dopunska literatura

Reynolds PA, Smolen GA, Palmer RE, Sgroi D, Yajnik V, Gerald WL, Haber DA (septembar 2003). "Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein". Genes & Development. 17 (17): 2094–107. doi:10.1101/gad.1110703. PMC 196452. PMID 12923058.
Dominguez CX, Müller S, Keerthivasan S, Koeppen H, Hung J, Gierke S, Breart B, Foreman O, Bainbridge TW, Castiglioni A, Senbabaoglu Y, Modrusan Z, Liang Y, Junttila MR, Klijn C, Bourgon R, Turley SJ (februar 2020). "Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy". Cancer Discovery. 10 (2): 232–253. doi:10.1158/2159-8290.CD-19-0644. PMID 31699795.
Buechler MB, Pradhan RN, Krishnamurty AT, Cox C, Calviello AK, Wang AW, Yang YA, Tam L, Caothien R, Roose-Girma M, Modrusan Z, Arron JR, Bourgon R, Müller S, Turley SJ (maj 2021). "Cross-tissue organization of the fibroblast lineage". Nature. 593 (7860): 575–579. doi:10.1038/s41586-021-03549-5. PMID 33981032 Provjerite vrijednost parametra |pmid= (pomoć).
Wang Y, Liu Y, Zhang M, Lv L, Zhang X, Zhang P, Zhou Y (mart 2018). "LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation". Stem Cell Res Ther. 9 (1): 65. doi:10.1186/s13287-018-0809-1. PMC 5845373. PMID 29523191.
Cui J, Dean D, Wei R, Hornicek FJ, Ulmert D, Duan Z (septembar 2020). "Expression and Clinical Implications of Leucine-Rich Repeat Containing 15 (LRRC15) in Osteosarcoma". J Orthop Res. doi:10.1002/jor.24848. PMID 32902907.
O'Prey J, Wilkinson S, Ryan KM (juni 2008). "Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy". Journal of Virology. 82 (12): 5933–9. doi:10.1128/JVI.02273-07. PMC 2395123. PMID 18385238.
Satoh K, Hata M, Yokota H (januar 2002). "A novel member of the leucine-rich repeat superfamily induced in rat astrocytes by beta-amyloid". Biochemical and Biophysical Research Communications. 290 (2): 756–62. doi:10.1006/bbrc.2001.6272. PMID 11785964.
Satoh K, Hata M, Shimizu T, Yokota H, Akatsu H, Yamamoto T, Kosaka K, Yamada T (septembar 2005). "Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix". Biochemical and Biophysical Research Communications. 335 (2): 631–6. doi:10.1016/j.bbrc.2005.07.117. PMID 16098915.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172061 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052316 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Leucine rich repeat containing 15".

[UniProt-6] "UniProt, Q8TF66" (jezik: engleski). Pristupljeno 8. 11. 2021.

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