A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members (Q24314405)

BCL2 apoptosis regulator

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BCL2 associated X, apoptosis regulator

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positive regulation of protein-containing complex assembly

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protein heterodimerization activity

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J L Diaz

1

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T Oltersdorf

2

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W Horne

3

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M McConnell

4

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G Wilson

5

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S Weeks

6

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T Garcia

7

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L C Fritz

Journal of Biological Chemistry

8

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language of work or name

English

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publication date

25 April 1997

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published in

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volume

272

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issue

17

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page(s)

11350-5

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cites work

Apoptosis in the pathogenesis and treatment of disease

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Mechanisms and genes of cellular suicide

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Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

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Cell killing by the Drosophila gene reaper

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

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In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

21 January 2018

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

21 January 2018

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Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors

21 January 2018

1 reference

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Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases

21 January 2018

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

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Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

21 January 2018

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Induction of apoptosis by the Bcl-2 homologue Bak

21 January 2018

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Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

21 January 2018

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Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

21 January 2018

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BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

21 January 2018

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Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

21 January 2018

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Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

21 January 2018

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Bcl-x(S) anatagonizes the protective effects of Bcl-x(L).

21 January 2018

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

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Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.

21 January 2018

1 reference

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Combinatorial interaction of human bcl-2 related proteins: mapping of regions important for bcl-2/bcl-x-s interaction.

21 January 2018

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Involvement of the bcl-2 gene in human follicular lymphoma

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1074/JBC.272.17.11350

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

9111042

1 reference

Consolidated OpenCitations Corpus – April 2017