Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin (Q37110578)

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scientific article published on 29 December 2008

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Language	Label	Description	Also known as
English	Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin	scientific article published on 29 December 2008

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instance of

scholarly article

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Europe PubMed Central

PMC publication ID

2648237

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18 August 2017

title

Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin (English)

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PMC publication ID

2648237

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18 August 2017

author name string

Alfredo Toschi

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1

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2648237

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Evan Lee

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2

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2648237

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18 August 2017

Limei Xu

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3

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2648237

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18 August 2017

Avalon Garcia

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4

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2648237

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18 August 2017

Noga Gadir

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5

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2648237

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18 August 2017

David A Foster

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6

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2648237

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18 August 2017

language of work or name

English

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publication date

29 December 2008

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Europe PubMed Central

PMC publication ID

2648237

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18 August 2017

published in

Molecular and Cellular Biology

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18 August 2017

volume

29

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issue

6

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page(s)

1411-1420

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2648237

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18 August 2017

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Phospholipase D1 is an effector of Rheb in the mTOR pathway.

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Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

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Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras

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14 September 2017

Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR

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Defining the role of mTOR in cancer

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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14 September 2017

Regulation of mTOR by phosphatidic acid?

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PubMed Central

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14 September 2017

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

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14 September 2017

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

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14 September 2017

mTOR and cancer: insights into a complex relationship

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PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals

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14 September 2017

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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An expanding role for mTOR in cancer

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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Targeting mTOR-mediated survival signals in anticancer therapeutic strategies

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

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14 September 2017

Will mTOR inhibitors make it as cancer drugs?

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14 September 2017

Phospholipase D in cell proliferation and cancer

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14 September 2017

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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14 September 2017

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

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Role for phospholipase D in receptor-mediated endocytosis

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Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity.

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Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.

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Suppression of TGF-beta signaling by phospholipase D.

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29 September 2017

HIF alpha expression in VHL-deficient renal cancer cells is dependent on phospholipase D.

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PubMed Central

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29 September 2017

Defective TGF-beta signaling sensitizes human cancer cells to rapamycin

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PubMed Central

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29 September 2017

Phospholipase D couples survival and migration signals in stress response of human cancer cells

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PubMed Central

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29 September 2017

Alternative phospholipase D/mTOR survival signal in human breast cancer cells

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PubMed Central

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29 September 2017

Molecular analysis of mammalian phospholipase D2.

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27 June 2018

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

1 reference

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PubMed Central

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3 September 2018

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

1 reference

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PubMed Central

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3 September 2018

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

1 reference

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PubMed Central

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3 September 2018

Phospholipase D confers rapamycin resistance in human breast cancer cells

1 reference

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PubMed Central

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3 September 2018

Identifiers

DOI

10.1128/MCB.00782-08

1 reference

stated in

Europe PubMed Central

PMC publication ID

2648237

retrieved

18 August 2017

PMC publication ID

2648237

1 reference

stated in

Europe PubMed Central

PMC publication ID

2648237

retrieved

18 August 2017

PubMed publication ID

19114562

1 reference

stated in

Europe PubMed Central

PMC publication ID

2648237

retrieved

18 August 2017

ResearchGate publication ID

23711772

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