Phospholipase D1 is an effector of Rheb in the mTOR pathway. (Q34786317)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550814%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

Phospholipase D1 is an effector of Rheb in the mTOR pathway (English)

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8 January 2020

5

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8 January 2020

author name string

Y Sun

1

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8 January 2020

Y Fang

2

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8 January 2020

M-S Yoon

3

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8 January 2020

C Zhang

4

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8 January 2020

F J Zwartkruis

6

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8 January 2020

M Armstrong

7

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8 January 2020

H A Brown

8

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8 January 2020

J Chen

9

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8 January 2020

language of work or name

English

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publication date

11 June 2008

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550814%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

8 January 2020

number of pages

6

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based on heuristic

inferred from page(s)

published in

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8 January 2020

volume

105

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8 January 2020

issue

24

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8 January 2020

page(s)

8286-8291

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550814%20AND%20SRC:MED&resulttype=core&format=json

PLD regulates myoblast differentiation through the mTOR-IGF2 pathway

8 January 2020

cites work

1 reference

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Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway

8 July 2018

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Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

8 July 2018

1 reference

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Regulation of mTOR by phosphatidic acid?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals

8 July 2018

1 reference

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The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle

8 July 2018

1 reference

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Growing roles for the mTOR pathway

8 July 2018

1 reference

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

8 July 2018

1 reference

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Regulation of the small GTPase Rheb by amino acids.

8 July 2018

1 reference

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hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

8 July 2018

1 reference

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Rheb binds and regulates the mTOR kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Upstream and downstream of mTOR

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

TSC2: filling the GAP in the mTOR signaling pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Rheb fills a GAP between TSC and TOR.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Activation of astroglial phospholipase D activity by phorbol ester involves ARF and Rho proteins.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral

8 July 2018

1 reference

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Mammalian phospholipase D structure and regulation

8 July 2018

1 reference

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Regulation of phospholipase D.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Functional association between Arf and RalA in active phospholipase D complex

8 July 2018

1 reference

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Relocalization of phospholipase D activity mediates membrane formation during meiosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2448829

PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0712268105

Phospholipase D confers rapamycin resistance in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0712268105

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0712268105

Peroxiredoxin II functions as a signal terminator for H2O2-activated phospholipase D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0712268105

Measurement of Phospholipase D Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0712268105

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0712268105

21 January 2018

Identifiers

DOI

10.1073/PNAS.0712268105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550814%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550814%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

18550814

1 reference