Pages that link to "Q40966106"

The following pages link to Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production (Q40966106):

Displaying 34 items.

• Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing (Q24290265) ‎ (← links)
• Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth (Q24633569) ‎ (← links)
• A novel mechanism for the regulation of amyloid precursor protein metabolism (Q24674865) ‎ (← links)
• Catalytic activity of human ADAM33 (Q28191609) ‎ (← links)
• Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice (Q30454134) ‎ (← links)
• PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling (Q33947097) ‎ (← links)
• Neuronal models to study amyloid precursor protein expression and processing in vitro (Q33971290) ‎ (← links)
• Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line (Q34586941) ‎ (← links)
• Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM. (Q34979489) ‎ (← links)
• The degradation of amyloid beta as a therapeutic strategy in Alzheimer's disease and cerebrovascular amyloidoses (Q35039021) ‎ (← links)
• The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism (Q35578655) ‎ (← links)
• Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. (Q35906413) ‎ (← links)
• Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease (Q36740290) ‎ (← links)
• Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant? (Q36939128) ‎ (← links)
• Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis (Q37175416) ‎ (← links)
• Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells (Q39038529) ‎ (← links)
• The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression (Q39968931) ‎ (← links)
• Identification and characterization of PEBP as a calpain substrate (Q40224274) ‎ (← links)
• Caspase cleaved presenilin-1 is part of active gamma-secretase complexes (Q40304488) ‎ (← links)
• Role of calreticulin in the sensitivity of myocardiac H9c2 cells to oxidative stress caused by hydrogen peroxide (Q40379206) ‎ (← links)
• Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage. (Q40451732) ‎ (← links)
• Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site (Q40506297) ‎ (← links)
• Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation (Q40601680) ‎ (← links)
• Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II. (Q40739303) ‎ (← links)
• Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2. (Q40798203) ‎ (← links)
• Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1. (Q40881378) ‎ (← links)
• Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice (Q41841473) ‎ (← links)
• Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons (Q42056692) ‎ (← links)
• Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. (Q42188322) ‎ (← links)
• Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability. (Q42496750) ‎ (← links)
• Regulation of reactive oxygen species and stress fiber formation by calpeptin in Swiss 3T3 fibroblasts (Q42819274) ‎ (← links)
• The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase (Q43510103) ‎ (← links)
• Nicastrin binds to membrane-tethered Notch (Q43694706) ‎ (← links)
• Direct metabolic regulation of beta-catenin activity by the p85alpha regulatory subunit of phosphoinositide 3-OH kinase (Q46427348) ‎ (← links)