The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression (Q39968931)

16 September 2017

title

The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression (English)

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16 September 2017

Catherine R Burton

1

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16 September 2017

Jere E Meredith

2

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16 September 2017

Donna M Barten

3

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16 September 2017

Margi E Goldstein

4

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16 September 2017

Carol M Krause

5

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16 September 2017

Cathy J Kieras

6

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16 September 2017

Lisa Sisk

7

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16 September 2017

Lawrence G Iben

8

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16 September 2017

Craig Polson

9

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16 September 2017

Mark W Thompson

10

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16 September 2017

Xu-Alan Lin

11

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16 September 2017

Jason Corsa

12

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16 September 2017

Tracey Fiedler

13

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16 September 2017

Maria Pierdomenico

14

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16 September 2017

Yang Cao

15

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16 September 2017

Arthur H Roach

16

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16 September 2017

Joseph L Cantone

17

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16 September 2017

Michael J Ford

18

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16 September 2017

Dieter M Drexler

19

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16 September 2017

Richard E Olson

20

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16 September 2017

Michael G Yang

21

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16 September 2017

Carl P Bergstrom

22

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16 September 2017

Kate E McElhone

23

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16 September 2017

Joanne J Bronson

24

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16 September 2017

John E Macor

25

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16 September 2017

Yuval Blat

26

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16 September 2017

Robert H Grafstrom

27

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16 September 2017

Andrew M Stern

28

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16 September 2017

Dietmar A Seiffert

29

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16 September 2017

Robert Zaczek

30

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16 September 2017

Charles F Albright

31

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16 September 2017

Jeremy H Toyn

32

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16 September 2017

language of work or name

English

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publication date

23 June 2008

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Journal of Biological Chemistry

16 September 2017

published in

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16 September 2017

volume

283

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16 September 2017

issue

34

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16 September 2017

page(s)

22992-23003

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

16 September 2017

cites work

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Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

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Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase

21 January 2018

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Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

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Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

21 January 2018

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A combinatorial approach to the identification of dipeptide aldehyde inhibitors of beta-amyloid production

21 January 2018

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Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production

21 January 2018

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Calpain inhibitor MDL28170 modulates Abeta formation by inhibiting the formation of intermediate Abeta46 and protecting Abeta from degradation

21 January 2018

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A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

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Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

21 January 2018

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Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

21 January 2018

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

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Adhesive force of a single gecko foot-hair.

21 January 2018

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Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

21 January 2018

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Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Al

21 January 2018

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The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

21 January 2018

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Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes

21 January 2018

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

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Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

21 January 2018

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

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Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

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Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice

21 January 2018

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Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates

21 January 2018

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Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.

21 January 2018

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A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation

21 January 2018

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Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

21 January 2018

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Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

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Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.

21 January 2018

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Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

21 January 2018

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DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

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Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

21 January 2018

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gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

21 January 2018

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The same gamma-secretase accounts for the multiple intramembrane cleavages of APP

21 January 2018

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Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

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When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

21 January 2018

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Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

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Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

21 January 2018

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The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

21 January 2018

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

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ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways.

21 January 2018

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Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment.

21 January 2018

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Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M804175200

1 reference

release_nsjei2prsrbuvoomulrh6jkckq

16 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nsjei2prsrbuvoomulrh6jkckq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference